| Japanese |
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| Title | 家兎VX-2癌における99mTc-Tetrofosminと99mTc-MIBIの腫瘍集積性に関する比較検討 |
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| Subtitle | 短報 |
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| Authors | 大塚信昭*, 玉田勉*, 三村浩朗*, 曽根照喜*, 森田浩一*, 友光達志*, 柳元真一*, 福永仁夫* |
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| Authors(kana) | |
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| Organization | *川崎医科大学核医学 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 10 |
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| Page | 939-943 |
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| Year/Month | 1997/10 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 要旨 最近, 心筋血流イメージ剤が腫瘍シンチグラフィに応用されている. これらのうち99mTc-tetrofosmin (99mTc-TF) と99mTc-MIBIについて家兎VX-2癌を用いて腫瘍集積性について比較検討を行った. VX-2癌を大腿部に移植後, 17〜21日目の担癌家兎7羽について腫瘍集積を初期像 (5分後) と後期像 (50分後) における軟部組織に対する腫瘍集積比にて算出した. 99mTc-TFと99mTc-MIBIの初期腫瘍集積性は同様に高いものの, 99mTc-TFは99mTc-MIBIに比してwashoutが早いことが示され, 腫瘍集積に対する両薬剤の違いが示唆された. 「I. はじめに」心筋血流シンチグラフィ製剤として開発された99mTc-hexakis-2-methoxy isobutyl-isonitrile (99mTc-MIBI) と, 99mTc-tetrofosmin (99mTc-TF) は各種腫瘍への集積が確認され, 腫瘍親和性放射性医薬品として注目されている. |
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| Practice | 臨床医学：一般 |
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| Keywords | Tumor scintigraphy, 99mTc-tetrofosmin, 99mTc-MIBI, VX-2 cancer. |
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| English |
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| Title | Comparative Study on the Tumor Accumulation of 99mTc-Tetrofosmin and 99mTc-MIBI in Rabbits Bearing VX-2 Cancer |
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| Subtitle | Short Communication |
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| Authors | Nobuaki OTSUKA, Tsutomu TAMADA, Hiroaki MIMURA, Teruki SONE, Koichi MORITA, Tatsushi TOMOMITSU, Shinichi YANAGIMOTO, Masao FUKUNAGA |
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| Authors(kana) | |
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| Organization | Department of Nuclear Medicine, Kawasaki Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 10 |
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| Page | 939-943 |
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| Year/Month | 1997/10 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Each of myocardial blood flow imaging agents has a potential usefulness as an agent for tumor scintigraphy. The tumor accumulation and washout of 99mTc-tetrofosmin and 99mTc-MIBI were comparatively studied using rabbits bearing VX-2 cancer. From seventeen to twenty days after the implantation of VX-2 cancer into the femoral region of seven rabbits, tumor to soft tissue accumulation ratio (T/S ratio) of each agent was calculated in early images (5 min after injection) and in late images (50 min after injection). Compared with 99mTc-tetrofosmin, the T/S ratio of 99mTc-MIBI was higher and, moreover, the washout was delayed. These results suggest that there is a difference in tumor accumulation property between these two agents. |
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| Practice | Clinical medicine |
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| Keywords | Tumor scintigraphy, 99mTc-tetrofosmin, 99mTc-MIBI, VX-2 cancer. |
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