| Japanese |
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| Title | 99mTc - MIBIによる原発性肺癌の原発病巣および縦隔リンパ節転移巣の評価 ; 201Tlとの比較ならびに化学療法の治療効果との関連について |
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| Subtitle | 原著 |
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| Authors | 長町茂樹*, 陣之内正史*, Leo G. FLORES II*, 大西隆*, 二見繁美*, 中原浩*, 田村正三*, 渡邊克司* |
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| Authors(kana) | |
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| Organization | *宮崎医科大学放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 7 |
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| Page | 453-463 |
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| Year/Month | 1997/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」原発性肺癌46例を対象に原発病巣46病巣, 縦隔転移リンパ節8病巣について99mTc-MIBI SPECTと201Tl SPECTによる描出能を比較検討した. 原発病巣では, 定量的指標として腫瘍と健側肺に関心領域を設定し, 早期・後期像のcount比よりEarly ratio(ER), Delayed ratio(DR)を求め, さらにRetention index(RI)を算出した. また, 小細胞癌6例については, 化学療法の効果と99mTc-MIBIの集積との関連についても検討した. 原発巣の陽性描出率は早期像を用いた場合99mTc-MIBIは201Tlとほぼ同等であったが後期像については, washoutする性質のため陽性率は著明に低下していた. 腫瘍径との関連では3cm以上の群で, 201Tlおよび99mTc-MIBIの早期像でいずれも90%以上であったが, 3cm未満の群では, 201Tlで37.5%, 99mTc-MIBIで25%であり, ER, DRも3cm以上の群と比較して低値を示した. 病理組織型別の検討では, 99mTc-MIBIにおいて扁平上皮癌で陽性率がやや低くwashoutする傾向が認められた. 縦隔リンパ節転移の検出能の検討では, sensitivityは201Tl早期像, 99mTC-MIBI早期像でいずれも62.5%, accuracyは96%で両薬剤とも同等であった. 小細胞癌において99mTc-MIBIの集積と抗癌剤治療効果との関連をPR群とNC群に分けて検討した結果ではNC群で集積程度が低く, 有意な洗い出しの亢進を認めたが, 症例数が少なく本法が抗癌剤治療効果推定に有用か否かについてはさらに検討する必要があると思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-MIBI, 201Tl-chloride, Lung cancer, Mediastinal lymph node metastasis. |
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| English |
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| Title | Evaluation of Primary Lung Cancer and Mediastinal Lymph Node Metastasis Using 99mTc - MIBI : Comparison with 201Tl and Relation to Chemotherapeutic Effect |
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| Subtitle | Original Articles |
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| Authors | Shigeki NAGAMACHI, Seishi JINNOUCHI, Leo G. FLORES II, Takashi OHNISHI, Hiroshi NAKAHARA, Shigemi FUTAMI, Syouzou TAMURA, Katsushi WATANABE |
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| Authors(kana) | |
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| Organization | Department of Radiology, Miyazaki Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 7 |
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| Page | 453-463 |
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| Year/Month | 1997/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]We compared the detectability of 99mTc-MIBI and 201Tl-chloride for primary lung cancer and mediastinal lymph node metastasis. We also analyzed the relationship between 99mTC-MIBI uptake and effectiveness of chemotherapy in patients with small cell lung cancer. The subjects were fourty-six primary lesions and 8 mediastinal metastatic lymph nodes confirmed by operation, and dual-isotope SPECT technique was performed at both 20 min and 180 min after tracer injection. A tumor to normal lung ratio on both early(ER)and delayed image(DR)and retention index(RI) were calculated. The positive rates of 99mTc-MIBI(early;82.6%, delayed;54.3%)were comparable to 201Tl in most primary tumor(87.0% and 84.8%). Whereas tumor smaller than 3 cm diameter was poorly visualized on both 99mTc-MIBI(25%and 0%)and 201Tl(37.5%and37.5%). Detectabilities of metastatic mediastinal lymph nodes of 99mTc-MIBI(62.5%and 25.0%)was comparable to those of 201Tl(62.5% and 50.0%). Regarding effectiveness of chemotherapy, NC group showed lower uptake of 99mTc-MIBI and significant lower value of RI compared to PR group. We concluded that early image of 99mTc-MIBI SPECT can be helpful in detecting primary lung cancer and metastatic mediastinal lymph node. Additionary, it might be useful for predicting the effects of chemotherapy in small cell lung cancer. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-MIBI, 201Tl-chloride, Lung cancer, Mediastinal lymph node metastasis. |
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