| Japanese |
|---|
| Title | 123I-IMPとSPECTを用いたAutoradiography (ARG) 法による安静時局所脳血流定量の再現性 |
|---|
| Subtitle | 技術報告 |
|---|
| Authors | 齋藤京子*, 村田啓**, 丸野広大**, 森一晃*, 土田昌一*** |
|---|
| Authors(kana) | |
|---|
| Organization | *虎の門病院放射線部, **放射線科, ***脳神経外科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 34 |
|---|
| Number | 5 |
|---|
| Page | 343-348 |
|---|
| Year/Month | 1997/5 |
|---|
| Article | 報告 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」123I-IMPとSPECTを用いたARG法から得られるrCBF値の再現性について検討した. SPECTとウエルカウンターのクロスキャリブレーションファクターの13か月間の変動範囲は2.2%であり, 装置は安定していた. 動脈採血時刻の差がrCBF値に与える影響は, 通常の採血範囲(IMP静注後, 10分±30秒)では2〜3%程度と考えられた. 10患者における1回目と2回目の安静時rCBF値の相関は良好であった(r=0.907). また, 1回目に対する2回目のrCBF値比の全脳平均は0.989±0.056(mean±SD)であり, 2回検査のrCBF値に有意な差を認めなかった. 以上のことから, ARG法の再現性は良好であり, 治療効果や経過観察の評価において有用な定量法であると考えられた. 「I. はじめに」N-isopropyl-p-[123I]iodoamphetamine(123I-IMP)とSPECTを用いた動脈一回採血とSPECT1回スキャンによる簡便な局所脳血流定量法としてautoradiography(ARG)法が秋田脳研から提唱された. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Reproducibility, 123I-IMP, SPECT, Autoradiography method, Regional cerebral blood flow. |
|---|
| English |
|---|
| Title | Reproducibility of Regional Cerebral Blood Flow Measurement at Rest with Autoradiography Method Using 123I - IMP and SPECT |
|---|
| Subtitle | Technical Report |
|---|
| Authors | Kyoko SAITO*, Hajime MURATA*, Hirotaka MARUNO*, Kazuaki MORI*, Shoichi TSUCHIDA** |
|---|
| Authors(kana) | |
|---|
| Organization | *Division of Nuclear Medicine, **Department of Neurosurgery, Toranomon Hospital |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 34 |
|---|
| Number | 5 |
|---|
| Page | 343-348 |
|---|
| Year/Month | 1997/5 |
|---|
| Article | Report |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary]Reproducibility of regional cerebral blood flow(rCBF)values obtained by the autoradiography(ARG)method with one SPECT scan and one point arterial blood sampling at 10min after 123I-N-isopropyl-p-iodoamphetamine(IMP)infusion was evaluated. The variation in the cross calibration factor between SPECT counts and well-type scintillation counts remained 2.2% for 13 months. The error in rCBF by sampling time difference was less than 3% when sampling time was within 10min+-30 sec after infusion. There was a favorable correlation between the rCBF values in two separate resting scans measured by the ARG method in 10 patients(r=0.907). And the mean ratio of rCBF values by the second study to those by the first study in the cerebellum and cerebral lobes in 10 patients was 0.989+-0.056(mean+-SD). There was no significant difference in rCBF values between two separate studies. Reproducibility of rCBF with the ARG method was proved to be good. The ARG method was thought to be useful for the assessment of treatment effects and clinical courses. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Reproducibility, 123I-IMP, SPECT, Autoradiography method, Regional cerebral blood flow. |
|---|