| Japanese |
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| Title | 99mTc-ECD SPECTによる海馬血流の評価 - 123I-IMP SPECTとの比較 - |
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| Subtitle | 《技術報告》 |
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| Authors | 松村要*, 渡辺佳夫**, 青木茂***, 中島弘道*, 前田寿登****, 平野忠則***, 竹田寛*, 中川毅* |
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| Authors(kana) | |
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| Organization | *三重大学医学部放射線科, **松阪中央総合病院神経内科, ***松阪中央総合病院放射線科, ****藤田保健衛生大学衛生学部診療放射線技術学科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 9 |
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| Page | 1021-1026 |
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| Year/Month | 1996/9 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99Tc-ECDを用いたSPECTにより, 各種脳疾患21例にて海馬血流の評価を行い, 123I-IMPによるSPECTと比較検討した. 用いた装置は3検出器型SPECT装置GCA9300A/HG(東芝社製)であり, TEW法散乱線補正後, 冠状断像, 海馬長軸断像を再構成した. 得られた画像より, 視覚的に海馬を含む側頭葉内側の集積を評価した. 12例(57%)にて, IMPに比してECDでの海馬描出は不良であった. 海馬病変の可能性がある6例(記憶障害4例, てんかん2例)の全例にECDでは海馬血流低下を疑う所見が見られたが, IMPでは3例のみに異常所見が見られ, 所見に乖離が見られた. 海馬長軸断像にて求めた側頭葉内側/外側カウント比はECDにて0.73±0.11であり, IMPの0.80±0.01に比して統計学的に有意に低値であった(p<0.001). すなわち, ECDはIMPよりも8.8%相対的に海馬への集積が低いことが示され, 両トレーサの脳内滞留機序の違いが分布に影響する一つの要因と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-ECD, 123I-IMP, SPECT, Hippocampus. |
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| English |
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| Title | Evaluation of Regional Cerebral Blood Flow in Hippocampus by 99mTc-ECD SPECT : Comparison With 123I-IMP SPECT |
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| Subtitle | |
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| Authors | Kaname MATSUMURA*, Yoshio WATANABE**, Shigeru AOKI***, Hiromichi NAKASHIMA*, Hisato MAEDA****, Tadanori HIRANO***, Kan TAKEDA*, Tsuyoshi NAKAGAWA* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Mie University School of Medicine, **Department of Neurology, ***Department of Radiology, Matsusaka Central General Hospital, ****Faculty of Radiological Technology, Fujita Health University School of Health Sciences |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 9 |
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| Page | 1021-1026 |
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| Year/Month | 1996/9 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | We evaluated regional cerebral blood flow in the hippocampus in 21 patients with neurological disorders by 99mTc-ethyl cysteinate dimer (ECD) SPECT and compared the findings with those by 123I-N-isopropyl-p-iodoamphetamine (IMP) SPECT. In all subjects, SPECT was taken using ECD (740 MBq) and IMP (167 MBq) using high performance SPECT (3-head SPECT, Toshiba GCA-9300A/HG) within 3 weeks interval. Regional uptake in the hippocampus was examined in the coronal sections and images parallel to the longitudinal axis of hippocampus. ECD and IMP showed similar hippocampal uptake in 9 cases, but ECD showed less uptake than IMP in 12 cases (57%). Regional counts in the hippocampus were related to the counts in the lateral temporal cortices and the mean count ratio was lower in ECD by 8.8% than that in IMP (0.73+-0.11 vs. 0.80+-0.11, p<0.001). In 6 patients suspected to have hippocampal lesion (4 cases of memory disturbance and 2 cases of epilepsy), all cases showed decreased uptake of ECD in hippocampus, but only 3 cases showed decreased uptake of IMP. This is suggestive to be relevant the difference in the retention mechanism of ECD and IMP, but further investigation should be performed. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-ECD, 123I-IMP, SPECT, Hippocampus. |
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