| Japanese |
|---|
| Title | 99mTc-GSAシンチグラフィによる肝機能の視覚的評価 - Grade分類に関する研究 - |
|---|
| Subtitle | 《原著》 |
|---|
| Authors | 大園洋邦* |
|---|
| Authors(kana) | |
|---|
| Organization | *久留米大学医学部放射線医学講座 |
|---|
| Journal | 核医学 |
|---|
| Volume | 33 |
|---|
| Number | 9 |
|---|
| Page | 935-942 |
|---|
| Year/Month | 1996/9 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」99mTc-GSAシンチグラフィを用いた簡便な肝機能の視覚的評価法である5段階評価によるGrade分類の有効性を肝細胞癌57例を含む76例について検討した. 99mTc-GSA 185 MBqを経静脈的にボーラス注入し, 投与後5分から6分の肝と心を含む前面のPlanar像を視覚的に5段階に分類し, 異なる読影者間でのGrade分類の一致率, 同一読影者における再現性の検討と, Grade分類と心/肝カウント比, LHL15, ICG15分血中停滞率(ICG R15), Alb, TB, PT, HPT, ZTTとの比較検討を行った. κテストによる異なる読影者間でのGrade分類の一致率, 同一読影者における再現性のκ値はそれぞれ平均0.92, 0.89と良好な成績を得た. 5段階評価によるGrade分類は心/肝カウント比, ICG R15, LHL15, Alb, TB, PT, HPT, ZTTとも良好な相関を示した. 5段階評価によるGrade分類は再現性に優れた簡便な肝機能の視覚的指標になると考えられた. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | 99mTc-GSA, Asialoglycoprotein receptor, Visual analysis, Grade scoring system, Hepatic function. |
|---|
| English |
|---|
| Title | Visual Analysis of Hepatic Function by a Scoring System Using 99mTc-GSA |
|---|
| Subtitle | - Original Articles - |
|---|
| Authors | Hirokuni OHZONO |
|---|
| Authors(kana) | |
|---|
| Organization | Department of Radiology, Kurume University School of Medicine |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 33 |
|---|
| Number | 9 |
|---|
| Page | 935-942 |
|---|
| Year/Month | 1996/9 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | To establish a simple hepatic function test, a fivepoint scoring system using 99mTc-galactosyl-human serum albumin (GSA) was applied to seventy-six patients with or suspected with hepatic dysfunction. Dynamic data at rest were obtained immediately and 30 minutes after intravenous bolus injection of 99mTc-GSA (185 MBq). Regions of interest (ROIs) were superimposed over the images of the liver and the entire heart. A visual analysis using a image taken 5 to 6 minutes after radiotracer injection was performed by the three observers blinded to the clinical information to assess their agreement or disagreement on the grading score. κ-Test was used to evaluate the goodness of agreement. Three pairs in the first reading showed excellent interobserver agreement (0.92 meanκ-value). Three pairs in the first and second reading also showed excellent intraobserver agreement (0.89 meanκ-value). Data were also analyzed for correlations with heart/liver count ratio, ICG R15, LHL 15, Alb, TB, PT, HPT and ZTT. There were good correlations between visual grading score and ICG R15 (Rs=0.619, p<0.0001) and between grading score and heart/liver count ratio (Rs=0.866, p<0.0001). Grading score was also correlated with LHL15, Alb, TB, PT, HPT and ZTT (Rs=-0.770; -0.580; 0.593; -0.544; -0.622; 0.518, p<0.0001 for each). There was a significant difference between heart/liver count ratio and LHL 15 in the Grade 4 and Grade 5 groups. In conclusion, the present data suggest that a five-point scoring system based on visual analysis using 99mTc-GSA uptake is a useful indicator for hepatic dysfunction in a clinical setting. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | 99mTc-GSA, Asialoglycoprotein receptor, Visual analysis, Grade scoring system, Hepatic function. |
|---|