| Japanese |
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| Title | 家兎VX-2癌における99mTc-HM-PAOおよび99mTc-MIBIの腫瘍集積性に関する研究 |
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| Subtitle | 短報 |
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| Authors | 大塚信昭*, 三村浩朗*, 森田浩一*, 小野志磨人*, 曽根照喜*, 永井清久*, 柳元真一*, 友光達志*, 浅野貴子*, 福永仁夫*, 亀井健**, 梶原康正** |
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| Authors(kana) | |
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| Organization | *川崎医科大学核医学教室, **放射線科教室 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 2 |
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| Page | 199-203 |
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| Year/Month | 1995/2 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」最近各種の血流イメージ剤が腫瘍シンチグラフィに応用されている. これらのうち, 脳血流シンチグラフィ製剤である99mTc-HM-PAOと心筋血流シンチグラフィ製剤である99mTc-MIBIの腫瘍シンチグラフィ製剤としての有用性を家兎VX-2癌を用いて比較検討した. VX-2癌を大腿部に移植後, 10〜20日目の種々の腫瘍サイズの担癌家兎6羽について, 初期像 (5分後) と後期像 (50分後) における軟部組織に対する腫瘍集積比を算出した. 99mTc-HM-PAOは99mTc-MIBIに比して初期集積率および腫瘍集積比は高く, またwashoutも遅れることが示され, 腫瘍集積性に対する両薬剤の違いが示唆された. 「I. はじめに」腫瘍シンチグラフィ製剤として, 67Ga-citrateや201Tl-Clなどのほかに最近では脳血流シンチグラフィ製剤である99mTc-hexamethyl propyleneamine oxime (99mTc-HM-PAO) の有用性が報告されている. |
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| Practice | 臨床医学：一般 |
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| Keywords | Tumor scintigraphy, 99mTc-HM-PAO, 99mTc-MIBI, VX-2 cancer |
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| English |
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| Title | Study On Tumor Accumulation Property of 99mTc-HM-PAO and 99mTc-MIBI in Rabbits Bearing VX-2 Cancer |
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| Authors | Nobuaki OTSUKA*, Hiroaki MIMURA*, Koichi MORITA*, Shimato ONO*, Teruki SONE*, Kiyohisa NAGAI*, Shinichi YANAGIMOTO*, Tatsushi TOMOMITSU*, Takako ASANO*, Masao FUKUNAGA*, Tsuyoshi KAMEI**, Yasumasa KAJIHARA** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, Kawasaki Medical School, **Department of Radiology, Kawasaki Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 2 |
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| Page | 199-203 |
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| Year/Month | 1995/2 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Each of blood flow imaging agents has a potential usefulness as an agent for tumor scintigraphy. The usefulness for tumor scintigraphy of two agents, i.e. cerebral blood flow scintigraphy agent 99mTc-HM-PAO and myocardial blood flow scintigraphy agent 99mTc-MIBI, was comparatively studied using rabbits bearing VX-2 cancer. From then to twenty days after the implantation of VX-2 cancer into the femoral region of five rabbits, tumor to soft tissue accumulation ratio (T/S ratio) of each agent was calculated in early images (5 min after injection) and in late images (50 min after injection). Compared with 99mTc-MIBI, the T/S ratio of 99mTc-HM-PAO was higher and, moreover, the washout was delayed. These results suggest that there is a difference in tumor accumulation property between these two agents. |
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| Practice | Clinical medicine |
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| Keywords | Tumor scintigraphy, 99mTc-HM-PAO, 99mTc-MIBI, VX-2 cancer |
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