| Japanese |
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| Title | 111In標識低比重リポ蛋白 (LDL) を用いたLDL体内分布および動脈硬化巣イメージングの検討 |
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| Subtitle | 原著 |
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| Authors | 山科久代* |
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| Organization | *東邦大学医学部付属大森病院内科学第一講座 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 7 |
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| Page | 769-778 |
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| Year/Month | 1993/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」111Inにて標識した低比重リポ蛋白(LDL)を, 遺伝性高脂血症家兎であるWatanabe heritable hyperlipidemic(WHHL)ウサギおよびコントロールウサギに投与し, その体内動態を, γ-カメラによるイメージング, 臓器放射能分布により検討した. 体外イメージングではいずれのウサギも肝, 心, 腎, 骨, 脾が描出され, 関心領域を設定して肝/心比を算出したところ, WHHL群にて有意に低値を認めた(p<0.05). LDLの血中半減期は同群で有意に長く, 臓器放射能分布は血液, 心, 大動脈で明らかに高値であった. 大動脈はオートラジオグラフィを施行し, WHHL群にて大動脈弓, 肋間・腹腔動脈分岐部の111In-DTPA-LDLの著明な集積を認めた. 今後, 標識LDLにより, リポ蛋白代謝および動脈硬化病変を表す体外イメージングが期待できる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 111In-DTPA-LDL, Atherosclerosis, Watanabe Heritable Hyperlipidemic(WHHL) rabbit. |
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| English |
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| Title | Evaluation of Biodistribution and Imaging of Atherosclerotic Lesions Using 111In-Labeled Low-Density Lipoprotein |
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| Subtitle | |
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| Authors | Hisayo YAMASHINA |
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| Authors(kana) | |
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| Organization | First Department of Internal Medicine, Toho University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 7 |
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| Page | 769-778 |
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| Year/Month | 1993/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]111In-labeled low-density lipoprotein (LDL) was administered to Watanabe heritable hyperlipidemic rabbits (WHHL group) and control rabbits (control group) to evaluate its biodistribution and scintigraphic images by γ-camera and radioactivity of each organ. With external imaging, the heart, liver, kidney, bone and spleen of each rabbit were observed. By setting the region of interest, the liver/heart ratio of the WHHL group was significantly lower than that of the control group (p<0.05), the plasma half life of LDL was longer and radioactivity in blood, heart and aorta was higher in the WHHL group. Each aorta was autoradiographed and significant accumulation of 111In-labeled-LDL was recognized in the aortic arch, bifurcation of intercostal and celiac artery in the WHHL group. By the use of labeled LDL with the combination of γ-camera, it is capable of detecting the regulation of lipoprotein metabolism and imaging atherosclerotic lesions externally. |
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| Practice | Clinical medicine |
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| Keywords | 111In-DTPA-LDL, Atherosclerosis, Watanabe Heritable Hyperlipidemic(WHHL) rabbit. |
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