| Japanese |
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| Title | 中枢神経系疾患における99mTc-ECD SPECTの有用性 - 特に123I-IMPおよび99mTc-HM-PAO SPECTとの比較 - |
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| Subtitle | 原著 |
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| Authors | 小野志磨人*, 柳元真一*, 三村浩朗*, 大塚信昭*, 永井清久*, 森田浩一*, 友光達志*, 村中明*, 渡辺明良**, 石井鐐二**, 福永仁夫* |
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| Authors(kana) | |
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| Organization | *川崎医科大学核医学科, **脳神経外科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 12 |
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| Page | 1429-1440 |
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| Year/Month | 1992/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」新しい脳血流測定用放射性医薬品である99mTc-ECDの臨床的有用性を検討した. 対象は14例(脳梗塞10例とその他4例)であり, 計15回の検査が施行された. また, ほぼ同時期に99mTc-HM-PAOまたは123I-IMPによるSPECTが行われ, 比較に供された. 病巣部と対側健常部のカウント比(L/N)に関しては, 血流低下の著明な症例では99mTc-ECDが最も低値であった. 一方, 血流低下が軽度の症例群では, 123I-IMPが最も低値を示した. 123I-IMPで求めた局所脳血流量と比較すると, 99mTc-ECDと99mTc-HM-PAOはともに高血流になるに従い, 直線性が低下した. Luxury Perfusionを示した症例では, 99mTc-ECDの集積は他の2剤とは異なり, 欠損様を呈した. 髄膜腫症例のDynamic SPECTでは腫瘍部の集積は経時的に大きく変化しており, 集積の評価には慎重を要すると思われた. 99mTc-ECDは脳血流測定用医薬品として有用であり, また一部の症例では代謝の一面を反映している可能性があるので今後多数例での詳細な検討が望まれる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-ECD SPECT, rCBF, Ischemic cerebral disease, 123I-IMP, 99mTc-HM-PAO. |
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| English |
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| Title | Usefulness of 99mTc-ECD SPECT in Diseases of Central Nerve System : Special Reference to Comparison to 123I-IMP and 99mTc-HM-PAO SPECT |
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| Subtitle | Original Articles |
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| Authors | Shimato ONO*, Shinichi YANAGIMOTO*, Hiroaki MIMURA*, Nobuaki OTSUKA*, Kiyohisa NAGAI*, Koichi MORITA*, Tatsushi TOMOMITSU*, Akira MURANAKA*, Akira WATANABE**, Ryoji ISHII**, Masao FUKUNAGA* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Neurosurgery, Kawasaki Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 12 |
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| Page | 1429-1440 |
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| Year/Month | 1992/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]The usefulness of a new cerebral perfusion imaging radiopharmaceutical, 99mTc-ethyl cysteinate dimer (ECD), was clinically evaluated. The subjects of this study were 14 patients with neurological disorders including 10 patients with cerebral infarction and 4 patients with other diseases. A total of 15 examinations was performed. 99mTc-HM-PAO or 123I-IMP SPECTs were performed simultaneously, and the findings from those examinations were compared with 99mTc-ECD. As to the count ratio of lesions to normal area (L/N), the L/N ratio in severe ischemic patients was lower in 99mTc-ECD than in 99mTc-HM-PAO or 123I-IMP. In mild ischemic patients, on the other hand, the L/N ratio was the lowest in 123I-IMP. When the relationship between rCBFs obtained from 123I-IMP and the values of L/N in 99mTc-ECD or 99mTc-HM-PAO was compared, the values of L/N in 99mTc-ECD Or 99mTc-HM-PAO were found to have decreased linearity with increasing rCBF. In a patient showing luxury perfusion, the accumulation pattern of 99mTc-ECD was different from that of the other two radiopharmaceuticals, and focal defect was revealed in 99mTc-ECD SPECT. On the dynamic SPECT of 99mTc-ECD in a patient with meningioma, the tumor showed a change from high to low perfusion with the passage of time. This finding indicated that care should be taken in the evaluation of accumulation of 99mTc-ECD. Therefore, 99mTc-ECD was found to be useful as a cerebral perfusion agent. In addition, as accumulation of 99mTc-ECD might somehow reflect metabolism in some cases, further careful investigation of many cases should be carried out. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-ECD SPECT, rCBF, Ischemic cerebral disease, 123I-IMP, 99mTc-HM-PAO. |
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