| Japanese |
|---|
| Title | 18F-FDGのマウス皮下移植FM3A腫瘍組織内での局在 : オートラジオグラフィーによる研究 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 窪田朗子*, 山田進*, 窪田和雄*, 石渡喜一**, 玉橋信彰***, 井戸達雄**** |
|---|
| Authors(kana) | |
|---|
| Organization | *東北大学抗酸菌病研究所放射線医学研究部門, **サイクロトロンラジオアイソトープセンター(現;東京都老人医学総合研究所ポジトロン医学研究施設), ***クラスターコア生物学研究所, ****東北大学サイクロトロンラジオアイソトープセンター |
|---|
| Journal | 核医学 |
|---|
| Volume | 29 |
|---|
| Number | 10 |
|---|
| Page | 1215-1221 |
|---|
| Year/Month | 1992/10 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」全身・マクロ・ミクロの3種類のオートラジオグラフィー法を用いて, 2-deoxy-2-18F-fluoro-D-glucose(FDG)の, マウス皮下移植FM3A腫瘍内における局在を調べた. これにより, FDGは, 腫瘍細胞だけでなく腫瘍と正常組織との境界に形成される, 線維芽細胞・マクロファージ・コラーゲン線維などが混在する若い肉芽組織や, あるいは, 壊死細胞と生きている腫瘍細胞との境界に見られるマクロファージに高い集積を示した. FDGの腫瘍集積は, 腫瘍細胞への集積と, 生体防御反応に基づく炎症細胞への集積の両面から, 検討を加える必要があると考えられる. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | 2-Deoxy-2-18F-fluoro-D-glucose, Autoradiography, Mouse FM3A cell line, Macrophages. |
|---|
| English |
|---|
| Title | Autoradiographic Demonstration of 18F-FDG Distribution within Mouse FM3A Tumor Tissue In Vivo |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Roko KUBOTA*, Susumu YAMADA*, Kazuo KUBOTA*, Kiichi ISHIWATA**, Nobuaki TAMAHASHI***, Tatsuo IDO**** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiology and Nuclear Medicine, Research Institute for Cancer and Tuberculosis, ****Cyclotron Radioisotope Center, Tohoku University, **Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, ***Clusterecore Institute of Biology |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 29 |
|---|
| Number | 10 |
|---|
| Page | 1215-1221 |
|---|
| Year/Month | 1992/10 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary]To demonstrate the distribution of 2-deoxy-2-18F-fluoro-D-glucose (FDG) within the tumor in vivo, C3H/He mice transplanted with FM3A tumors were studied one hour after intravenous injection of FDG using whole-body, macro- and micro-autoradiography. The whole-body autoradiograph showed that the tumor mass as well as the brain, heart, bone marrows, and the diaphram and crus diaphram were clearly visualized. The macroautoradiograph showed the heterogeneous distribution of FDG in the tumor mass. Markedly dense areas surrounding the tumor and the necrotic area were observed. Microautoradiograph showed the high grain densities in the macrophages between the necrosis and viable tumor cells, and in the young granulation tissues demarcating between the tumor and surrounding intact host tissues. Our results showed that the FDG uptake in the tumors may reflect not only the uptake by the tumor cells but also that by the inflammatory reaction elements. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | 2-Deoxy-2-18F-fluoro-D-glucose, Autoradiography, Mouse FM3A cell line, Macrophages. |
|---|