| Japanese |
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| Title | 111In標識抗CEAモノクローナル抗体 (ZCE-025) による大腸癌のイムノシンチグラフィに関する臨床的検討 |
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| Subtitle | 原著 |
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| Authors | 片山通章*, 中村佳代子*, 橋本禎介*, 塚谷泰司*, 藤井博史*, 橋本順*, 久保敦司*, 橋本省三*, 小平進**, 寺本龍生** |
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| Authors(kana) | |
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| Organization | *慶應義塾大学医学部放射線科, **外科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 9 |
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| Page | 1057-1065 |
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| Year/Month | 1991/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」大腸癌が疑われる患者5例に111In標識抗CEAマウスモノクローナル抗体ZCE-025によるイムノシンチグラフィを試み, その後の手術結果とイムノシンチグラフィの結果を比較し, その有用性について検討した. 手術の結果, 4例が大腸癌で1例が術後良性直腸狭窄であった. また大腸癌患者2例に肝転移が認められた. イムノシンチグラフィでは原発巣については4病巣すべてに明らかな陽性像が得られた. 術後良性直腸狭窄では111In標識ZCE-025の集積は認められなかった. 肝転移巣では2病巣中1病巣に陽性像が得られた. また1例でシンチグラフィ上リンパ節への強い集積が認められたが, 手術の結果リンパ節には腫瘍細胞がなく偽陽性を示した. なおZCE-025投与後4週間以内にヒト抗マウス抗体(HAMA)が全例に検出されたが, 5症例すべてについて他の副作用は認められなかった. 以上の結果からZCE-025によるイムノシンチグラフィは再発腫瘍と術後の変化との鑑別については有用性が高いと考えられるが, リンパ節転移の診断については偽陽性のでる可能性があり注意を要する. |
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| Practice | 臨床医学：一般 |
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| Keywords | Immunoscintigraphy, Monoclonal antibody, CEA, Indium labeled, Colorectal cancer. |
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| English |
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| Title | Immunoscintigraphy of Colorectal Cancer with 111In Labeled Anti-CEA Monoclonal Antibody (ZCE-025) |
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| Subtitle | Original Articles |
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| Authors | Michiaki KATAYAMA*, Kayoko NAKAMURA*, Teisuke HASHIMOTO*, Yasushi TSUKATANI*, Hirofumi FUJII*, Jun HASHIMOTO*, Atsushi KUBO*, Shozo HASHIMOTO*, Tatsuo TERAMOTO**, Susumu KODAIRA** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Surgery, School of Medicine, Keio University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 9 |
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| Page | 1057-1065 |
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| Year/Month | 1991/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Clinical trials with 111In labeled anti-CEA monoclonal antibody (ZCE-025) was initiated. Five patients with colorectal cancer suspected were given an intravenous injection of 1 mg of 111In labeled ZCE-025. Planar and SPECT images were obtained 24 and 72 hours after injection. Surgical operation was performed on all patients between 7 and 10 days post injection. Of 4 primary sites, all were clearly visualized. Intrahepatic metastasis was visualized as higher activity than normal liver in one of two patients. In one patient whose imaging was negative, no residual cancer was found at surgery. Persistent accumulation of 111In in the lymph nodes was also observed in one patient. Surgical exploration of these lymph nodes showed no gross or microscopic evidence of metastases of colon cancer. No side effects were encountered, although HAMA were detected in all 5 patients by 4 weeks after the administration of ZCE-025. Immunoscintigraphy appears useful in distinguishing recurrent tumor from postoperative granuloma. Further investigation directed to the causes of 111In accumulation in tumor-free lymph nodes is required. |
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| Practice | Clinical medicine |
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| Keywords | Immunoscintigraphy, Monoclonal antibody, CEA, Indium labeled, Colorectal cancer. |
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