| Japanese |
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| Title | 99mTc-EHIDAによる経直腸門脈シンチグラフィの実験的研究 |
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| Subtitle | ≪原著≫ |
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| Authors | 玉城聡*, 篠塚明*, 武中泰樹* |
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| Organization | *昭和大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 5 |
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| Page | 487-497 |
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| Year/Month | 1991/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」肝胆道シンチグラフィ製剤として広く用いられている99mTc-EHIDAが経直腸投与でも良好に吸収されて門脈シンチグラフィとして応用可能であることをみいだした. そこでその有用性を検討するために家兎を用いた実験を行った. 肝外門脈シャントモデルを作成し, 99mTc-RBC, 123I-IMP, 99mTc-EHIDAによる門脈シンチグラフィから求めたshunt indexと開腹下での下腸間膜静脈への99mTc-MAA注入により求めたシャント率との比較検討を行った. その結果, おのおのの相関係数は, 99mTc-RBCが0.64, 123I-IMPが0.75, 99mTc-EHIDAが0.78であり, 99mTc-EHIDAが最も優れており, その有用性が明らかとなった. 正常ボランティアでも良好な画像が得られ, 本法は臨床的にも応用可能な方法と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Per-rectal portal scintigraphy, 99mTc-EHIDA, 123I-IMP, 99mTc-RBC, 99mTC-MAA. |
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| English |
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| Title | Experimental Study of Per-rectal Portal Scintigraphy Using 99mTc-EHIDA |
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| Subtitle | - Original Articles - |
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| Authors | Satoshi TAMAKI, Akira SHINOTSUKA, Hiroki TAKENAKA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Showa University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 5 |
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| Page | 487-497 |
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| Year/Month | 1991/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We discovered that 99mTc-EHIDA commonly used for hepatobiliary scintigraphy could also be administered per-rectally, with adequate absorption and optimal visualization of the portal system. To evaluation its usefulness, we experimented on rabbits using the method. Portal scintigraphy with rectal administration of 99mTc-EHIDA, 123I-IMP and 99mTc-RBC were performed in normal rabbits and in extrahepatic portal shunt model rabbits. Images of the liver and thorax were obtained and shunt indices were calculated from the count values of liver and lung or heart. Then the shunt indices were compared with shunt rate derived from direct injection of 99mTc-MAA into inferior mesenteric vein. Correlation between shunt rato of 99mTc-MAA and shunt indices of 99mTc-RBC, 123I-IMP and 99mTc-EHIDA were 0.64, 0.75 and 0.78, respectively, with 99mTc-EHIDA having the most favourable results. We concluded that 99mTc-EHIDA per-rectal portal scintigraphy is a noninvasive, quantitative, inexpensive and simple method for evaluation of portal circulation system. Also, we think that this method would be appliable to human usage from our experience with normal volunteers. |
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| Practice | Clinical medicine |
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| Keywords | Per-rectal portal scintigraphy, 99mTc-EHIDA, 123I-IMP, 99mTc-RBC, 99mTC-MAA. |
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