| Japanese |
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| Title | N-isopropyl-p-iodoamphetamineの肝集積に関する実験的研究 |
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| Subtitle | 《原著》 |
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| Authors | 小須田茂*, 河原俊司**, 石橋章彦**, 田村宏平**, 久保敦司***, 橋本省三*** |
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| Organization | *都立駒込病院放射線診療科, **国立大蔵病院放射線科, ***慶應義塾大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 6 |
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| Page | 599-605 |
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| Year/Month | 1990/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」N-isopropyl-p-iodoamphetamineの肝集積機序を解明する目的で, Wister系雄性ラット5匹を用いて, 123I-IMP門脈投与による肝動態検査と同系ラット2匹を用いて125I-IMPによる肝ミクロオートラジオグラフィを施行した. 123I-IMP門脈投与により, 123I-IMPは肝内に高率に摂取され, 洗い出しも比較的速やかであった(静注後10分の肺/肝カウント比0.2, 0.15). 塩酸ケタミン5mg, 8mg負荷により123I-IMP肝集積は低下し, 静注直後より肺描出がみられた(静注後10分の肺/肝カウント比0.20). 肝ミクロオートラジオグラフィの検討では, 黒化度は中心静脈および洞様血管内に認められ, 肝実質細胞内には認められなかった. 以上の結果から, 肝内中心静脈の内皮細胞内の非特異的アミン受容体の存在が示唆されたが, 未だ実験動物数が少なく, 今後の研究がまたれる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Microautoradiography, 125I-IMP, 123I-IMP, Liver scanning, Portal vein. |
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| English |
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| Title | Experimental Study on Liver Accumulation of N-Isopropyl-p-Iodoamphetamine |
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| Subtitle | - Original Articles - |
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| Authors | Shigeru KOSUDA*, Shunji KAWAHARA**, Akihiko ISHIBASHI**, Kohei TAMURA**, Atsushi KUBO***, Shozo HASHIMOTO*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Tokyo Metropolitan Komagome Hospital, **Department of Radiology, Okura National Hospital, ***Department of Radiology, School of Medicine, Keio University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 6 |
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| Page | 599-605 |
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| Year/Month | 1990/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | In order to clarify the mechanism of N-isopropyl-p-iodoamphetamine (IMP) liver accumulation, liver dynamic study by the portal injection of 123I-IMP and liver microautoradiography by 125I-IMP were performed using 5, 2 male rats, respectively. The initial uptake of 123I-IMP in the liver was very high and thereafter 123I-IMP showed relatively rapid wash-out (count ratio of lung to liver at 10 min after the injection was 0.12, 0.15). On the other hand, the addition of 5 mg, 8 mg ketamine hydrochloride decreased the initial 123I-IMP liver uptake and its lung accumulation was noted immediately after the injection (count ratio of lung to liver at 10 min was 0.20). Microautoradiography of the liver using 125I-IMP showed grain density in the central vein and sinusoids, but not in the liver parenchymal cell. These results suggest that non-specific amine receptor (binding site) may exist in the endothelial cell in the central vein, although the number of experimental rats in this series was small for conclusion. |
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| Practice | Clinical medicine |
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| Keywords | Microautoradiography, 125I-IMP, 123I-IMP, Liver scanning, Portal vein. |
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