| Japanese |
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| Title | 直鎖脂肪酸IPPA [ω- (p-iodophenyl) -pentadecanoic acid] の心筋イメージングへの応用 - 心筋梗塞モデルを用いて - |
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| Subtitle | 原著 |
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| Authors | 河村康明*, 山崎純一*, 奥住一雄*, 内孝*, 武藤敏徳*, 中野元*, 若倉学*, 岡本淳*, 細井宏益*, 森下健*, 高野政明**, 高橋秀樹** |
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| Authors(kana) | |
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| Organization | *東邦大学医学部内科学第一講座, **核医学検査室 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 10 |
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| Page | 1295-1301 |
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| Year/Month | 1989/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 直鎖脂肪酸アナログIPPA[ω-(P-iodophenyl)-pentadecanoic acid]を用いて, 基礎的検討および心筋イメージングへの応用を試みた. 白色家兎 (n=6) におけるIPPAの生体内分布の時間推移では肝への集積が高値に保たれ, 30分後において81.0%であるのに対し, 心臓・肺・腎の30分後はおのおの, 30.0%, 10.0%, 15.0%であり, 特に心臓では3分値48.0%より急激な減少を呈し, β酸化の影響によるものと考えられた. 一方, 心筋梗塞モデルを成犬にて作製し, IPPA3mCiを投与すると (n=6) 全例において前下行枝梗塞領域の欠損像を示し, IPPAが心筋症などの心筋代謝疾患だけでなく, 急性期の虚血性心疾患への応用が可能であり, また慢性的な虚血や潜在性の虚血など, 従来のタリウムシンチでは虚血の存在が証明困難であった疾患に対して本剤の有用性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Myocardial metabolism, Iodinated straight chain fatty acid, Acute myocardial infarction |
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| English |
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| Title | Application of Straight Chain Fatty Acid Analog IPPA [ω-(p-Iodophenyl)-Pentadecanoic Acid] for Myocardial Imaging - Using Acute Myocardial Infarction Model - |
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| Subtitle | Original Articles |
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| Authors | Yasuaki KAWAMURA*, Junichi YAMAZAKI*, Ichio OKUZUMI*, Takashi UCHI*, Toshinori MUTO*, Hajime NAKANO*, Manabu WAKAKURA*, Kiyoshi OKAMOTO*, Hiromitsu HOSOI*, Takeshi MORISHITA*, Masaaki TAKANO**, Hideki TAKAHASHI** |
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| Authors(kana) | |
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| Organization | *The First Department of Internal Medicine, Toho University School of Medicine, **Division of Nuclear Medicine, Toho University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 10 |
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| Page | 1295-1301 |
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| Year/Month | 1989/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Application for myocardial imaging and fundamental experiments were studied using straight chain fatty acid analog IPPA [ω-(P-iodophenyl)-pentadecanoic acid]. Biodistribution of IPPA in rabbits (n=6) shows the accumulation in liver was maintained 81.0% at 30 minutes, while the accumulations in heart, lungs and kidneys were 30.0%, 10.0% and 15.0% respectively. Especially the accumulation of heart decreased rapidly from 48.0% at 3 minutes to 30.0% at 30 minutes, reflecting the effect of β oxidation. On the other hand, in the acute myocardial infarction mode (n=6) , with occlusion in left anterior descending coronary artery, all 6 cases showed defect images at the corresponding areas after injection of 3 mCi of IPPA. Myocardial imaging with IPPA should be useful not only for myocardial metabolic diseases (cardiomyopathy etc.) but also for ischemic heart disease. |
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| Practice | Clinical medicine |
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| Keywords | Myocardial metabolism, Iodinated straight chain fatty acid, Acute myocardial infarction |
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