| Japanese |
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| Title | I-123IMP肺集積に関する気管支肺胞洗浄による検討 |
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| Subtitle | 原著 |
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| Authors | 板坂美代子*, 池田英樹*, 八鍬直*, 加藤修一*, 高橋敬治*, 安井昭二* |
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| Organization | *山形大学医学部第一内科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 2 |
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| Page | 189-194 |
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| Year/Month | 1989/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 肺疾患患者10名(肺線維症4名, 肺癌2名, その他4名)を対象に, I-123IMPの集積部位および肺内動態について検討した. 対象患者に1.5mCiのI-123IMPを静注し, 約40分後に気管支肺胞洗浄を施行した. 同時に静脈血を採血した. 気管支肺胞洗浄液(BAL-T)・洗浄液の上清(BAL-F)・血清(B-S)のI-123IMPの放射活性をウェル型シンチレーション・カウンターにて測定した. 洗浄液の細胞成分(BAL-C)の放射活性はBAL-TとBAL-Fの差より求めた. BAL-T/B-Sは平均6.86, BAL-F/B-Sは4.26, BAL-C/B-Sは2.71となった. 静注されたI-123IMPは, 肺毛細管内皮細胞に取り込まれた後, 肺胞腔に能動輸送され, さらに肺胞腔内細胞に高率に取り込まれていると考えられた. 疾患肺におけるI-123IMPの肺野からの消失の遅延には, 肺毛細管内皮の取り込み機能だけでなく, 肺胞腔への移動と蓄積も関与していると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-isopropyl-p-iodoamphetamine (I-123 IMP), Broncho-alveolar lavage (BAL), Lung, Non-respiratory lung function |
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| English |
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| Title | The Study of the Lung Accumulation of I-123 IMP by the Broncho-alveolar Lavage |
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| Authors | Miyoko ITASAKA, Hideki IKEDA, Naoshi YAKUWA, Shuichi KATO, Keiji TAKAHSHI, Shoji YASUI |
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| Authors(kana) | |
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| Organization | The First Department of Internal Medicine, Yamagata University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 2 |
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| Page | 189-194 |
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| Year/Month | 1989/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We studied the accumulated portion and the movement of I-123 IMP in the lung. Ten subjects were studied. They were four patients with fibrosing lung disease, two with lung cancer, and four with other lung disease. They underwent the broncho-alveolar lavage (BAL) for the diagnosis of their disease. 1.5 mCi of I-123 IMP was injected into the ante-cubital vein. The BAL examination was carried out about 40 minutes after the injection of I-123 IMP. The subjects' blood was sampled at the same time. The total BAL liquid (BAL-T) was divided into the fluid component (BAL-F) and the cell component (BAL-C) by centrifugation. The radioactivities in BAL-T, BAL-F, BAL-C, and serum (B-S) were measured by the well-counter. The average of BAL-T/B-S, BAL-F/B-S and BAL-C/B-S were 6.86, 4.26 and 2.71 respectively. It was confirmed that I-123 IMP was transported from the pulmonary capillary to the alveolar space and was taken up by the alveolar cells. It was considered that the analysis of the I-123 IMP release from the lung showed not only the endothelial cell uptake function but also the interstitial and material cells' amine transport and uptake function. |
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| Practice | Clinical medicine |
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| Keywords | N-isopropyl-p-iodoamphetamine (I-123 IMP), Broncho-alveolar lavage (BAL), Lung, Non-respiratory lung function |
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