| Japanese |
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| Title | 99mTc標識微粒子活性炭による乳房リンパ節シンチグラフィの基礎的検討 |
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| Subtitle | 研究速報 |
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| Authors | 前田正敏*, 佐伯俊雄**, 唐木芳昭**, 宗像周二**, 藤巻雅夫**, 瀬戸光***, 本田昂* |
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| Authors(kana) | |
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| Organization | *富山医科薬科大学放射性同位元素実験施設, **第二外科学, ***放射線医学 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 8 |
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| Page | 809-812 |
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| Year/Month | 1988/8 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. 緒言」最近の初発乳癌術式の縮小化傾向に伴って, 合理的なリンパ節郭清法の確立が望まれており乳腺リンパ流の解析は, その一助になると考えられる. 従来より様々な製剤を用いたリンパ流の解析が検討されてきているが, 十分にこの目的を満たす製剤は見当たらない. 著者らは, リンパ指向性の高い微粒子活性炭に着目してきた. この微粒子活性炭は, 生体内で肉眼的に明瞭に識別できる特徴があるためリンパ節郭清に有利であり, さらに放射性核種で標識した場合には, リンパ流の解析が精度よく, 定量的にできるのではないかと考えられる. 99mTc標識活性炭を調製することを試み, 標識化に成功したので報告する. また, リンパ節シンチグラフィへの適用の可能性についても検討したので, あわせて報告する. 「II. 材料」微粒子活性炭は, 粒子径21nmのCH44(三菱化成製)で分散補助剤としてポリビニールピロリドンを添加し5%懸濁生理食塩水として調製した. |
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| Practice | 臨床医学：一般 |
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| Keywords | Technetium-99m labeled activated carbon microspheres, In vitro stability, Breast cancer, Lymph flow, Lymphoscintigram. |
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| English |
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| Title | Study of Mammary Lymph Node Scintigraphy by Tc-99m Labeled Activated Carbon Microspheres |
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| Subtitle | |
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| Authors | Masatoshi MAEDA*, Toshio SAEKI**, Yoshiaki KARAKI**, Shuji MUNAKATA**, Masao FUJIMAKI**, Hikaru SETO***, Takashi HONDA* |
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| Authors(kana) | |
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| Organization | *RI Laboratory, **Second Department of Surgery, ***Department of Radiological Science, Toyama Medical and Pharmaceutical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 8 |
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| Page | 809-812 |
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| Year/Month | 1988/8 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | The establishment of rational lymph node dissection is hoped following reductive operation of the breast cancer. The simultaneous analysis of lymph flow will be useful for this purpose. We report the preparation of Tc-99m labeled activated carbon microspheres for analysis of lymph flow. The labeling of activated carbon microspheres by Tc-99m was made by the EDTA complex method. Five mCi of Tc-99m was added to 3 mg of SnCl2, 0.5ml of 1% EDTA solution, 2ml of 5% activated carbon microspheres suspension. The stability in vitro was examined for 24 hr at 37°C. The extent of release was examined with the mobility of Tc-99m from labeled activated carbon microspheres in a semipermeable membrane tube to human plasma. The labeling rate was more than 93% and the stability in vitro was more than 97% at 24hr. The releasing ratio was 12% at 1 hr. Therefore it was suggested the labeling of activated carbon microspheres by Tc-99m was useful for the analysis of lymph flow. |
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| Practice | Clinical medicine |
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| Keywords | Technetium-99m labeled activated carbon microspheres, In vitro stability, Breast cancer, Lymph flow, Lymphoscintigram. |
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