| Japanese |
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| Title | 指運動および音読時における局所脳血流変化の検討 - N-Isopropyl-p-[123I]Iodoamphetamine静注法と133Xe吸入法の比較 - |
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| Subtitle | 短報 |
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| Authors | 松田博史*, 関宏恭*, 石田博子*, 久田欣一* |
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| Organization | *金沢大学医学部核医学 |
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| Journal | 核医学 |
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| Volume | 21 |
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| Number | 7 |
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| Page | 859-865 |
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| Year/Month | 1984/7 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」生理的刺激による脳代謝や脳血流の変化を捕えることは, 大脳生理学上, また脳血管障害患者の機能回復過程を知る上でも重要である. この目的には, 従来133Xe脳クリアランス法が用いられてきたが, 分解能に劣ること, また通常の装置では2次元情報しか得られないことなどの欠点を有する. これに対し, 近年ポジトロン核種を用いる方法が応用され, 詳細な機能解剖図が得られるようになってきた. しかし, この方法もポジトロンCT装置や院内サイクロトロンを必要とし, 巨額な投資となるため一般的でない. 1980年, Winchellらによって開発されたN-Isopropyl-p-[123I]Iodoamphetamine(123I-IMP)は, 初回循環で高率に脳組織に取りこまれ, しかも組織からの洗い出しが遅いため, 脳血流測定用剤として注目されている. しかし, 本剤を用いて生理的刺激時の脳血流の変化を捕えた報告としては, Hillらの閉眼時と開眼時での報告がみられるのみである. |
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| Practice | 臨床医学：一般 |
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| Keywords | Regional cerebral blood flow change, Finger movement, Reading aloud, N-Isopropyl-p-[123I]Iodoamphetamine intra-venous injection method, 133Xe inhalation method. |
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| English |
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| Title | Regional Cerebral Blood Flow Changes During Finger Movement and Reading Aloud - Comparison Between N-isopropyl-p-[123I]Iodoamphetamine Intra-venous Injection and 133Xe Inhalation Methods - |
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| Subtitle | Short Communication |
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| Authors | Hiroshi MATSUDA, Hiroyasu SEKI, Hiroko ISHIDA, Kinichi HISADA |
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| Authors(kana) | |
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| Organization | Department of Nuclear Medicine, School of Medicine, Kanazawa University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 21 |
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| Number | 7 |
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| Page | 859-865 |
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| Year/Month | 1984/7 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Regional cerebral blood flow changes during left finger movement (Motor Sequence Test) and reading aloud, obtained by N-Isopropyl-p-[123I]-Iodoamphetamine (123I-IMP) intra-venous injection method were compared with those obtained by 133Xe inhalation method in normal right-handed subjects. 123I-IMP injection method showed that left finger movement was accompanied by focal increases in prefrontal cortex, both supplementary motor areas, right primary sensorimotor hand area and right central gray matter, and that reading aloud was accompanied by focal increases in primary visual cortex, visual striate cortex, prefrontal cortex, both supplementary motor areas, left prefrontal eye field, Broka's area, Wernicke's area and left angular gyrus. On the other hand, 133Xe inhalation method could neither distinguish focal increase in supplementary motor area from that in primary sensorimotor hand area during left finger movement, nor detect any focal increase other than that in occipital and left postero-suprior temporal regions during reading aloud. 123I-IMP injection method is superior in both spacial resolution and accuracy to 133Xe inhalation method, and is useful in evaluating regional cerebral blood flow changes during physiologic activations. |
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| Practice | Clinical medicine |
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| Keywords | Regional cerebral blood flow change, Finger movement, Reading aloud, N-Isopropyl-p-[123I]Iodoamphetamine intra-venous injection method, 133Xe inhalation method. |
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