| Japanese |
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| Title | N-Isopropyl-P-[123I]Iodoamphetamineによる局所脳血流測定 |
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| Subtitle | 研究速報 |
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| Authors | 松田博史*, 関宏恭*, 石田博子*, 久田欣一*, 古林秀則**, 林実**, 山本信二郎** |
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| Organization | *金沢大学医学部核医学教室, **脳神経外科学教室 |
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| Journal | 核医学 |
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| Volume | 21 |
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| Number | 5 |
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| Page | 445-448 |
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| Year/Month | 1984/5 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」 1980年Winchellらによって開発されたN-Isopropyl-p-[123I]Iodoamphetamine (IMP) は, 初回循環で高率に脳組織に取りこまれ, しかも組織からの洗い出しが遅いため, 新しい脳血流測定用剤として注目されている. IMP静注後ごく初期の間では脳よりの洗い出しをほとんど無視しうるため, 脳血流の絶対値を求める際に計算式はマイクロスフエアを動注した場合とほぼ同様になる. このことを利用してKuhlらは本剤の静注直後より多検出器型Emission Computed Tomography (ECT) を用いて, 同一スライス面を50秒ごとで繰り返し約8分後まで撮像することにより脳血流測定を行っている. しかし, 彼らの方法では脳の限られた断層面しか測定できない. これに対し, ガンマカメラ回転型ECTは1回の測定で任意の断層面が得られる特徴を有し, これを利用しての脳血流分布像はすでに報告されている. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-Isopropyl-p-[123I]Iodoamphetamine, rCBF, Rotating gamma camera ECT |
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| English |
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| Title | Regional Cerebral Blood Flow Measurement by N-Isopropyl-p-(123I)Iodoamphetamine |
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| Subtitle | Rapid Communication |
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| Authors | Hiroshi MATSUDA*, Hiroyasu SEKI*, Hiroko ISHIDA*, Kinichi HISADA*, Hidenori KOBAYASHI**, Minoru HAYASHI**, Shinjiro YAMAMOTO** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Neurosurgery, School of Medicine, Kanazawa University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 21 |
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| Number | 5 |
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| Page | 445-448 |
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| Year/Month | 1984/5 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Regional cerebral blood flow (rCBF) measurement was performed on a patient after subarachnoid hemorrhage by N-Isopropyl-p-[123I]Iodoamphetamine (IMP) and rotating gamma camera emission computed tomography (ECT) equiped with medium energy collimator. The equation for determining rCBF is as follows : F=100・R・Cb/(N・A) , where F is rCBF in ml/100g/min., R is the constant withdrawal rate of arterial blood in ml/min., Cb is the brain activity concentration in μCi/g, A is the total activity (5 min.) in the withdrawal arterial whole blood in μCi and N is the fraction of A that is true tracer activity. Cb and A were determined by ECT and couting in a well counter, respectively. X-ray CT showed a dilatation of anterior horn of the right ventricle and bilateral periventricular lucencies, especially on right side. rCBF values for right frontal lobe, left frontal lobe, right thalamic portion, left thalamic portion, right temporal lobe, left temporal lobe and occipital lobe were 13, 23, 30, 31, 29, 26 and 28 ml/100 g/min., respectively at the level of OM+4 cm. The advantage of rCBF measurement using IMP and rotating gamma camera ECT is that it is not only entire brain but also three dimensional measurement in comparison with conventional 133Xe clearance or 81mKr injection method. |
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| Practice | Clinical medicine |
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| Keywords | N-Isopropyl-p-[123I]Iodoamphetamine, rCBF, Rotating gamma camera ECT |
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