| Japanese |
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| Title | In-111-Oxine標識好中球による炎症巣の描出 |
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| Subtitle | 原著 |
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| Authors | 内田立身*, 松田信*, 油井徳雄*, 木村秀夫*, 田中鉄五郎*, 刈米重夫*, 木田利之** |
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| Authors(kana) | |
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| Organization | *福島県立医科大学第一内科, **放射線科 |
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| Journal | 核医学 |
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| Volume | 18 |
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| Number | 4 |
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| Page | 441-447 |
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| Year/Month | 1981/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | <要旨> 最近開発された111In-oxine complexを用いて好中球を標識し, あらかじめ炎症の存在が確認されている症例に投与したところ, 炎症部位に標識好中球の明瞭な集積を認めた. 111In-oxine標識好中球は標識率が高く, phagocytosis indexやtrypan-blueでのviabilityも障害されておらず, i111In-oxine complexを用いると標識は比較的簡単であった. 好中球寿命も正常例においてはt1/2 : 7時間とDF32Pで報告された値に一致し, 好中球減少を伴う炎症例では1.0時間と短かく, しかも翌日, 炎症巣の膿の中に高濃度の放射能が認められ, すみやかに炎症巣に動員されることがうかがわれた. 本法は炎症巣の確認や検索に有用であるのみならず, 好中球の動態を知る上にも寿命と臓器分布を同時に観察できる利点があって優れていることを示唆した. |
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| Practice | 臨床医学：一般 |
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| Keywords | In-111-oxine, In-111-oxine labeled neutrophils, Inflammation, Neutrophil Kinetics. |
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| English |
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| Title | Detection of Infiammatory Sites by In-111-Oxine Labeled Neutrophils |
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| Subtitle | Original Articles |
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| Authors | Tatsumi UCHIDA*, Shin MATSUDA*, Tokuo YUI*, Hideo KIMURA*, Tetsugoro TANAKA*, Shigeo KARIYONE*, Toshiyuki KIDA** |
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| Authors(kana) | |
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| Organization | *The First Department of Internal Medieine and **Department of Radiology, Fukushima Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 18 |
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| Number | 4 |
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| Page | 441-447 |
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| Year/Month | 1981/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Neutrophil labeling was performed by using recently developed 111In-oxine complex. 111Inoxine-labeled neutrophils injected into the patients with inflamation were significantly accumulated in the infected area. 111In could label neutrophils with the advantages of higher labeling efficiency, normal viability due to phagocytosis index and trypan blue exclusion test, and simple labeling procedure. Neutrophil survival labeled with 111In-oxine in a normal patient was 7.0 hours of T-1/2 and that in a neutropenic patient was 1.0 hour, in which higher radioactivity was detected in the collected pus 24 hours after the infusion. This technique would be utilized not only in the detection of inflammatory sites, but in simultaneous observation of neutrophil survival and organ distribution in the field of neutrophilic kinetic studies. |
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| Practice | Clinical medicine |
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| Keywords | In-111-oxine, In-111-oxine labeled neutrophils, Inflammation, Neutrophil Kinetics. |
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