| Japanese |
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| Title | 冠動脈結紮およびその再灌流が201Thallium-Cl心筋scintigraphyに与える影響に関する実験的研究 |
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| Subtitle | 原著 |
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| Authors | 金子義伸* |
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| Organization | *東京医科大学内科第二講座 |
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| Journal | 核医学 |
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| Volume | 18 |
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| Number | 1 |
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| Page | 23-39 |
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| Year/Month | 1981/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 雑種成犬30頭を用い冠動脈を種々の時間結紮またはそれを再灌流し201Tl心筋scintigramの動態を観察しFluorescein Na (F-Na) 螢光像と病理組織像をも合わせ検討した. 結紮群では短期から長期結紮にわたり201Tlの取り込み低下がみられたが, 長期結紮の犬心臓の201Tl欠損像は範囲がせまく判別困難であったが病理組織像では心室壁の著明な菲薄化がみられた. 201Tlを結紮前に投与し結紮15分後心摘出した群はF-Na螢光像ではその血流途絶部位は螢光欠損像を示したがその部位での201Tlの取り込み低下はみられなかった. 再灌流群では再灌流期間に関係なく結紮6時間以内では201Tlの取り込みの低下はなくF-Na螢光像でも欠損像はみられなかった. 12時間〜6時間結紮後に再灌流した群は, 血流途絶部位での201Tlの取り込みの低下がみられ, また病理組織学的には不可逆性の変化を示していた. 以上の成績より虚血部位での201Tlの取り込み低下は血流と心筋障害の程度を正確に反映しうる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Thallium-201, Coronary occlusion, Coronary reperfusion, Fluorescein Na method, Histopathology. |
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| English |
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| Title | Canine Myocardial Images by 201Thallium-Cl Scintigraphy After Coronary Occlusion with and without Reperfusion |
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| Subtitle | |
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| Authors | Yoshinobu KANEKO |
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| Authors(kana) | |
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| Organization | The Second Department of Internal Medicine, Tokyo Medical College Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 18 |
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| Number | 1 |
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| Page | 23-39 |
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| Year/Month | 1981/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Ligation of the coronary artery was performed in 30 dogs. Twelve dogs underwent reperfusion, and in all dogs 201Tl scintigraphy was performed in addition to examination with sodium fluuroescein and pathohistological studies. Uptake of 201Tl was seen to decrease with the period of ligation. In long term ligation, the range of the 201Tl defect in the canine heart was narrow and differentiation was difficult, but pathohistologically remarkable thinning of the ventricular wall was observed. In 3 dogs which received preligation administration of 201Tl and heart resection 15 minutes after ligation, fluorescent defects were observed in the occluded areas but there was no noticeable decrease in 201Tl. In all reperfused cases, regardless of the reperfusion time, the decrease of 201Tl uptake disappeared within 6 hours and no defects were observed on sodium fluorescein studies after reperfusion. In cases reperfused after 12 hours-6 days ligation, decrease in 201Tl uptake and irreversible pathohistological changes were observed. These results showed that 201Tl uptake accurately reflected circulatory and myocardial disturbance. |
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| Practice | Clinical medicine |
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| Keywords | Thallium-201, Coronary occlusion, Coronary reperfusion, Fluorescein Na method, Histopathology. |
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