Japanese
Title全身骨シンチグラフィーによる慢性血液透析患者における腎性骨異栄養症の臨床的検討
Subtitle原著
Authors木田利之*, 成田滋**
Authors(kana)
Organization*福島県立医科大学放射線科学教室, **公立藤田綜合病院内科
Journal核医学
Volume15
Number7
Page1005-1011
Year/Month1978/10
Article原著
Publisher日本核医学会
Abstract「要旨」: 腎性骨異栄養症の形態学的評価は, 主としてレ線学的検査方法を用いて行われていた. 骨シンチグラフィーは, 局所的または全身的骨変化を鋭敏に表現し, しかも骨性代謝異常をよく反映するので, われわれは臨床的ならびに生化学的検査成績で, 明らかに二次性副甲状腺機能亢進症であると診断された慢性透析患者15例に99mTc-MDPよる骨シンチグラフィーを行い, シンチグラム所見について検討した. 患者に5〜10mCiを静注し, 3時間後に1 : 7の縮小率で, 前面および後面の全身像を得た. 検討結果は次の通りである. 1) シンチ像では, 15例全例にRI異常集積像を認めたが, レ線像では6例 (40%) に異常を認めたにすぎなかった. このことは, 腎性骨異栄養症の診断には, レ線学的検査よりも骨シンチグラフィーの方が優っていることを暗示している. 2) 透析期間とレ線像ならびにシンチ像で認めた骨異常の程度および範囲との関係をみると, シンチ像では相関はみられず, 一方, レ線像では長期間透析例にのみ異常を認めた. 3) 骨シンチグラフィーで, もっともしばしば骨異常を認めた部位は, 大関節, 胸骨, 肋骨, 脊椎および骨盤であった. 4) 全身骨シンチグラフィーは, 腎性骨異栄養症の補助的診断法として非常に有用である.
Practice臨床医学：一般
KeywordsWhole body skeletal scintiphotography, 99mTc-methylene diphosphonate, Renal osteodystrophy.
English
TitleClinical Study of Renal Osteodystrophy in Chronic Dialysis Patients by Means of Whole Body Skeletal Scintiphotography
SubtitleOriginal Articles
AuthorsToshiyuki KIDA*, Shigeru NARITA**
Authors(kana)
Organization*Department of Radiology, Fukushima Medical College, **Department of Internal Medicine, Fujita General Hospital
JournalThe Japanese Journal of nuclear medicine
Volume15
Number7
Page1005-1011
Year/Month1978/10
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] Morphological evaluation of renal osteodystrophy has mostly been performed using bone roentgenological examination. As skeletal scintiphotography is a highly sensitive indicator of focal and generalized skeletal disorders and reflects the osseous metabolic turnover, we have studied 99mTc-methylene diphosphonate (99mTc-MDP) skeletal scintiphotographic findings in 15 patients on chronic dialysis, with clinical and laboratory evidence of secondary hyperparathyroidism. Patients received a dose of 5 - 10 mCi 99mTc-MDP intravenously, and anterior and posterior whole body scans were obtained with 1 : 7 minification about 3 hours later. The results are as follows : 1) All 15 patients (100%) had abnormal accumulation on the scintigrams. In contrast roentgenographic abnormalities were present in only 6 patients (40%). Therefore, this result suggests that scintiphotography is superior to conventional roentgenological techniques in the early detection of skeletal changes. 2) No correlation could be demonstrated between the degree and extent of scintiphotographic abnormalities and the length of hemodialysis period, while roentgenographic changes were noticed only in the long-term dialysis patients. 3) The most frequently involved regions found by scintiphotography were the large joints, sternum, ribs, spines and pelvis. 4) The whole body skeletal scintiphotography is very useful as a supplementary diagnostic method of renal osteodystrophy.
PracticeClinical medicine
KeywordsWhole body skeletal scintiphotography, 99mTc-methylene diphosphonate, Renal osteodystrophy.

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