| Japanese |
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| Title | 201Tl Chlorideによる悪性腫瘍の診断 |
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| Subtitle | 原著 |
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| Authors | 矢野潔*, 森田誠一郎**, 古川保音**, 梅崎典良***, 古賀尚充*, 河野彬**, 尾関己一郎**, 大竹久** |
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| Authors(kana) | |
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| Organization | *福岡県立柳川病院放射線科, **久留米大学医学部放射線科, ***久留米大学医学部放射性同位元素施設 |
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| Journal | 核医学 |
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| Volume | 15 |
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| Number | 7 |
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| Page | 989-997 |
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| Year/Month | 1978/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」: 201Tl chlorideによる腫瘍スキャンが可能であることを知り, 腫瘍イメージに応用してみた. 応用に先立ってBleomycinとの結合を試みたが成功しなかった. 201Tl chloride単独にて腫瘍スキャンを行い, 動物実験および臨床的な観察を行った. 動物実験においては, 腫瘍の摂取率は大体1%前後で, 他の腫瘍親和性物質と大差なく腫瘍スキャンの可能性を示唆した. 臨床的には, 悪性腫瘍での陽性率は74.7%で他の腫瘍親和性物質と大差なく, また二核種併用 - 67Ga citrateと197HgCl2 - の場合においてもその陽性率に差異はみとめられなかった. 201Tlによる腫瘍スキャンは, 投与直後より得られるので便利であり, 腫瘍スキャンに十分に利用しうる薬剤と思われる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 201Tl, Tumor scan. |
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| English |
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| Title | Diagnosis of Malignant Neoplasm with 201Tl Chloride |
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| Subtitle | Original Articles |
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| Authors | Kiyoshi YANO*, Seiichiro MORITA**, Yasuto FURUKAWA**, Noriyoshi UMEZAKI***, Hisamitsu KOGA*, Akira KOONO**, Miichiro OZAKI**, Hisashi OOTAKE** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Yanagawa Public Hospital, **Department of Radiology, Kurume University, School of Medicine, ***Radioisotope Institute, Kurume University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 15 |
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| Number | 7 |
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| Page | 989-997 |
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| Year/Month | 1978/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Prior to the present study, we tried to combine 201Tl with Bleomycin with unsuccessful results. The incorporation of 201Tl chloride into malignant tumor tissue was observed in animal experiments as well as in clinical study. 1) The animal experiments of mice with Ehrilich tumor : The uptake rate in tissues were higher in kidney and pancreas than tumor tissue and heart muscle. The uptake rate in tumor was about 1.0 - 2.0% of administered dose and was the same with the other tumor seeking substances, for example, 197HgCl2, 67Ga citrate and 57Co-BLM. 2) Clinical study : The positive rate of 201TlCl in malignant neoplasms was 74.7% (68 cases / 91 cases). In 30 cases of malignant tumors that were scanned either with 67Ga citrate or 197HgCl2 and with 201TlCl, the positive rate was almost equal. The incorporation of 201TlCl into tumor was clinically observed and the results obtained showed that the incorporation curve became plateau after 200 sec., which meant that tumor scan with 201TlCl should be started shortly after administration. Consequently, 201Tl seemed to be an useful agent as a tumor Scanning agent. |
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| Practice | Clinical medicine |
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| Keywords | 201Tl, Tumor scan. |
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