Japanese
Title新しい肝胆道系Radionuclide 99mTc-Pyridoxylideneisoleucineの使用経験
Subtitle原著
Authors堀田とし子*, 有水昇*, 川名正直*, 三好武美*, 内山暁**, 大川治夫***
Authors(kana)
Organization*千葉大学医学部放射線科, **千葉大学医学部付属病院放射線部, ***千葉大学医学部小児外科
Journal核医学
Volume15
Number5
Page721-729
Year/Month1978/8
Article原著
Publisher日本核医学会
Abstract「要旨」小児12例を含む55例に対して99mTc-PIによる肝胆道シンチグラフィーを行った. さらに, computer処理全身スキャン, 経時的採血を加え動態撮像と体内分布の変化などを検討した. 1) A群 : 正常11例では従来の131I BSPよりもContrastの良い画像が得られ, 10分でヘパトグラム, 20分には胆管, 総胆管の描出, 30分では胆のう, 腸管の描出が鮮明に得られる. 収縮剤投与後30〜60分に撮像を加え, 肝胆道系のdynamic full studyが短時間に可能である. 2) B群 : 胆のう描出あるも異常な22例では胆のう描出が45〜60分と遅れ, 収縮剤に対する反応も不充分であり90〜120分を要する. 3) C群 : 胆のう描出のない18例では肝へのRadionuclideとり込み悪く, 総胆管の描出も遅く拡張し, 肝濃度の低下も遅延し画像も悪い. この群では尿路系からのRN排泄が増加する. 4) 正常例4例に対し施行した3〜4回全身連続スキャンのROIを検討すると, 肝胆道系へは全身の45〜55%, 膀胱へは7〜11%RNが集積している. 5) 血中濃度の経時的変化 : 肝機能正常群では30分後に20%, 60分後10%まで低下するが, 転移性肝腫瘍例では30分45%, 60分35%と高値を示している. 6) 小児例では24〜72時間を要する131I BSPに比べて99mTc-PIは24時間studyで胆道系の情報が得られる. 7) 正常例を含め, 静注後2〜5分の早期に腎影が出るため, 障害陰影となりやすい. 特に高度な肝障害, 乳児肝炎などではほとんどのRNが尿路系から排泄される. 8) 今回の55例に関して副作用は全くなく肝・胆道系のスクリーニング的検査として臨床上有用と認められる.
Practice臨床医学：一般
Keywords99mTc-PI, Scintigraphy, Biliary, Distribution, Dynamics
English
TitleStudies on 99mTc-Pl (Pyridoxylideneisoleucine) A new Radionuclide of Hepato-Biliary Scintigraphy
SubtitleOriginal Articles
AuthorsToshiko HOTTA*, Noboru ARIMIZU*, Masanao KAWANA*, Takemi MIYOSHI*, Guio UCHIYAMA*, Haruo OHKAWA**
Authors(kana)
Organization*Department of Radiology, Faculty of Medicine, **Department of Pediatric Surgery, Faculty of Medicine, Chiba University
JournalThe Japanese Journal of nuclear medicine
Volume15
Number5
Page721-729
Year/Month1978/8
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] Hepato-biliary scintigraphies with 99mTc-Pyridoxylideneisoleucine were performed to 55 cases, including 12 childhood cases. Computed wholebody scintigraphies and continuous blood sampling were added, for getting dynamic study and organ distribution changes. 1) In Group A of 11 normal cases, images with better contrast were obtained, in comparison to 131I BSP scan. Hepatogram was obtained in 10 minutes, images of common bile ducts in 20 minutes, and clear images of gallbladder and intestine in 30 minutes. Imaging in 30 and 60 minutes after administration of contractile agent were added thereafter. Fulldynamic study was possible in a short time. 2) In Group B of 22 cases, visualization of gallbladder was delayed to 45 or 60 minutes. Reaction to contractile agents was not enough, taking 90 or 120 minutes. 3) In Group C of 18 cases, visualization of gallbladder was not obtained. Hepatic uptake of the radionuclide was poor, visualization of common bile duct delayed with dilatation, and thinning of liver images was slow. In this group of cases, urinary excretion was increased. 4) In the study of 3 or 4 times whole body continuous scan on 4 normal cases, it was 45 or 55% in hepato-biliary system and 7 or 11% in urinary bladder. 5) Changes of blood concentration in time : In a group of cases with normal liver function, it was lowered into 20% in 30 minutes and 10% in 60 minutes. In cases with metastatic liver tumors, it was high to be 45% in 30 minutes and 35% in 60 minutes. 6) In pediatric cases, 99mTc-PI study was possible in 24 hours for getting good information of hepato-biliary system. On the other hand, in 131I-BSP scan it takes 24 or 72 hours. 7) In 2 or 5 minutes, kidney visualization was shown even in normal cases. It could be a disturbing image. Especially in the cases with severe liver malfunction, almost all RN was excreted from Urinary System. 8) No side effect was observed in this series of 55 cases. This method using 99mTc-PI was believed to be a valuable screening test for hepato-biliary system.
PracticeClinical medicine
Keywords99mTc-PI, Scintigraphy, Biliary, Distribution, Dynamics

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