| Japanese |
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| Title | Radioimmunosorbent test法によるIgEの測定について |
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| Subtitle | 原著 |
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| Authors | 金尾啓右, 井上雅代, 松雪銀彦, 弘重尚久, 三河春樹 |
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| Organization | 住友病院臨床検査部内科小児科 |
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| Journal | 核医学 |
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| Volume | 10 |
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| Number | 2 |
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| Page | 91-97 |
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| Year/Month | 1973/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「はじめに」1966年石坂らによるIgEの発見以来多くの検討が重ねられた結果, IgEがアトピーの病像の形成に大きな部分を占めることが推定されるに至っている. このIgEの定量法についてはradial immunodiffusion法およびradioimmunoassay法(radioimmunosorbent test: RIST)があり, Bersonらによって確立されたradioimmunoassay法によるものは最も感度よく測定される. 最近になってSwedenのPharmacia社によって開発されたIgE radioimmunosorbent test(Phadebas IgE test kit)がわが国へ供給されるようになったことから, われわれはこのkitを用いることによりIgEの測定を日常化するために基礎的検討ならびに若干の臨床的応用を試みたので得られた成績について報告する. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | On the Measurment of IgE by Radioimmunosorbent Test |
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| Subtitle | Original |
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| Authors | K.KANAO, M.INOUE, Y.MATSUYUKI, N.HIROSHIGE, H.MIKAWA |
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| Organization | Radioisotope Laboratory, Sumitomo Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 10 |
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| Number | 2 |
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| Page | 91-97 |
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| Year/Month | 1973/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | A sensitive method for measuring serum IgE level has been developed by the radiommunoassay techique. Fundamental investigation and mersurment of IgE level of healthy individuals and cases with various diseases by using Phadebas IgE radioimmunosorbent Kit were performed. The results were as follows. 1) Fundamental investigation by Phadebas IgE radioimmunosorbent Kit suggested that it was possible in clinical application to determine serum IgE level. 2) Serum IgE level in healthy individual is less than 50 U/ml up to 1 year after birth, thereafter, increases gradually with age and reaches to about 500 U/ml of adult level. 3) Abnormal high level of serum IgE is mostly limited to atopic diseases with the exception of a few other diseases as essential eosinophilia. 4) In 6 cases with Behcet's disease, the relationship between IgE and other immnoglobulins was investigated. IgG and IgM were parallel to low level of IgE, but IgA was within normal limit. 5) In some of children with bronchial asthma treated with specific hyposensitization therapy, the transient rise of IgE was recognized in the short period of 1-2 months after the begining of the therapy, but a fall of IgE level could be suspected 1-2 years after the therapy. 6) There was extreme difference between the level of IgE in serum from the mothers and that of their respective newborns (cord serum), and the same difference was found between the level of IgE in serum and liquor cerebrosphinalis. 7) Slight gradual rise of IgE level during pregnancy and short period after delivery was noted. |
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| Practice | Clinical medicine |
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