| Japanese |
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| Title | 99mTc-MIBIにおける同日2回投与検査法の安全性および臨床的有用性の評価 - 第III相多施設共同試験報告 - |
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| Subtitle | 技術報告 |
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| Authors | 久保敦司*1, 橋本順*1, 中嶋憲一*2, 利波紀久*2, 今井嘉門*3, 日下部きよ子*4, 小林秀樹*4, 田中健*5 |
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| Authors(kana) | |
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| Organization | *1慶應義塾大学医学部放射線科, *2金沢大学医学部核医学科, *3埼玉県立循環器・呼吸器病センター循環器内科, *4東京女子医科大学放射線科, *5心臓血管研究所内科 |
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| Journal | 核医学 |
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| Volume | 35 |
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| Number | 9 |
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| Page | 929-938 |
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| Year/Month | 1998/11 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」心疾患患者107例を対象として99mTc-MIBIを用いた安静(Re)時と運動負荷(Ex)時の同日2回投与検査法の安全性および臨床的有用性を多施設臨床試験にて検討した. 安全性の検討では, 運動負荷に伴う一過性の血圧低下が1例に認められたが, 99mTc-MIBIに明らかに起因した副作用はなかった. 画質はEx像にて95.0%以上, Re像にて100%で「きわめて鮮明」あるいは「鮮明」と判定された. 冠動脈造影の有意狭窄病変(75%狭窄以上)に対する本検査法の感度は84.3%であった. さらに投与時条件Re-ExまたはEx-Reの相違による感度の有意差は認めなかった. 有効性は96.2%と高い評価であった. また, 有意狭窄病変群では, 比較的高い心筋虚血の検出が可能であった. 99mTc-MIBIを用いた安静時および運動負荷時の2回の投与を同日に行う一日法は, 安全性が高く, 良質な画像と有効な情報が十分に得られる労作時虚血の迅速な診断方法であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-MIBI, One day protocol, Coronary artery disease, Myocardial ischemia. |
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| English |
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| Title | Evaluation of the Safety and Clinical Feasibility of Exercise 99mTc-MIBI SPECT Using One Day Protocol - Multicenter Phase III Clinical Trial Report - |
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| Authors | Atsushi KUBO*1, Jun HASHIMOTO*1, Kenichi NAKAJIMA*2, Norihisa TONAMI*2, Kamon IMAI*3, Kiyoko KUSAKABE*4, Hideki KOBAYASHI*4, Takeshi TANAKA*5 |
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| Authors(kana) | |
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| Organization | *1Department of Radiology, School of Medicine, Keio University, *2Department of Nuclear Medicine, School of Medicine, Kanazawa University, *3Department of Cardiology, Saitama Cardiovascular and Pulmonary Center, *4Department of Radiology, Tokyo Women's Medical College, *5Department of Internal Medicine, The Cardiovascular Institute |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 35 |
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| Number | 9 |
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| Page | 929-938 |
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| Year/Month | 1998/11 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | We evaluated the safety and clinical usefulness of the same day protocol of exercise 99mTc-MIBI SPECT in 107 patients with heart diseases. No adverse event was observed except for one case of transient hypotension caused by the exercise. More than 95% of stress images and all of the rest images were judged as "Excellent" or "Good" in image quality. Overall sensitivity was 84.3% in detecting coronary artery disease, and no statistical difference was observed between the results obtained with Re-Ex and Ex-Re protocols. The examination was "Quite Effective" or "Effective" in diagnostic efficacy in 96.2% of the cases. We concluded that the same day protocol is a safe and useful method for diagnosing myocardial ischemia, which provides high image quality and valuable information. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-MIBI, One day protocol, Coronary artery disease, Myocardial ischemia. |
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