| Japanese |
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| Title | SPMを用いたアルツハイマー型痴呆における脳血流低下領域の検討 - 重症度別解析について - |
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| Subtitle | 原著 |
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| Authors | 熊倉嘉貴*, 百瀬敏光*, 奥真也*, 大嶽達*, 西川潤一*, 大友邦* |
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| Organization | *東京大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 35 |
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| Number | 9 |
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| Page | 843-848 |
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| Year/Month | 1998/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」アルツハイマー型痴呆の進行に伴う脳血流低下領域を明らかにするため, 正常群10例, 軽度アルツハイマー型痴呆群9例と高度アルツハイマー型痴呆群9例に対し, 123I-IMP脳血流SPECTを施行し, 画像のTalairach標準脳図譜上への変換と統計処理をSPM'95を用いて行った. 正常群と軽度アルツハイマー型痴呆群の比較では, 従来の報告と同様に側頭頭頂連合野と帯状回後部の血流低下がみられたが, アルツハイマー型痴呆の軽度群と高度群の比較では前脳基底部と右海馬の血流低下が示された. アルツハイマー型痴呆の進行過程において, 同部位の機能低下が関与している可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Dementia of Alzheimer's type, Regional cerebral blood flow, Single photon emission computed tomography, Statistical parametric mapping. |
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| English |
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| Title | Stepwise Analysis of Cerebral Blood Flow SPECT Imaging on Standard Brain Atlas in Patients with Dementia of Alzheimer's Type |
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| Subtitle | Original Articles |
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| Authors | Yoshitaka KUMAKURA, Toshimitsu MOMOSE, Shinya OKU, Tohru OHTAKE, Junichi NISHIKAWA, Kuni OHTOMO |
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| Authors(kana) | |
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| Organization | Department of Radiology, Faculty of Medicine, University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 35 |
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| Number | 9 |
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| Page | 843-848 |
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| Year/Month | 1998/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Statistical parametric mapping (SPM) has been developed by Friston et al. to analyze focal changes in regional cerebral blood flow (rCBF) induced by brain activation. This automated and objective approach has the potential of being applied to single photon emission computed tomography (SPECT) image data sets. This study evaluated an automated analysis of N-isopropyl-p-[123I]iodoamphetamine SPECT (123I-IMP) imaging in patients with dementia of Alzheimer's type (DAT) using statistical parametric mapping '95 (SPM'95). Eighteen patients with clinically diagnosed mild to severe DAT who were classified into two groups and ten normal control subjects were studied. The SPECT device used was a triple-headed rotation gamma camera. All images were transformed into the standard anatomical space of the stereotaxic brain atlas of Talairach and Tournoux, and then smoothed. Statistical analyses were made between severe DAT, mild DAT and normal control groups. SPM analysis of 123I-IMP SPECT images revealed that the parietotemporal association areas and posterior cingulate gyri of both cerebral hemispheres were significantly decreased in CBF in mild DAT group compared to normal controls. In comparison of DAT groups, the right hippocampal area and basal forebrain were significantly decreased in CBF in severe DAT group. In conclusion, these results obtained by SPM analysis of SPECT images suggested that the right hippocampal area and basal forebrain followed the parietotemporal association areas and posterior cingulate gyri in the reduction of the rCBF in patients with DAT. |
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| Practice | Clinical medicine |
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| Keywords | Dementia of Alzheimer's type, Regional cerebral blood flow, Single photon emission computed tomography, Statistical parametric mapping. |
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