| Japanese |
|---|
| Title | 123I-MIBGシンチグラフィを用いた神経芽細胞腫の診断 - 病期分類のための撮像方法の検討 - |
|---|
| Subtitle | 原著 |
|---|
| Authors | 奥山智緒*, 牛嶋陽*, 杉原洋樹*, 興津茂行*, 前田知穂* |
|---|
| Authors(kana) | |
|---|
| Organization | *京都府立医科大学放射線科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 35 |
|---|
| Number | 9 |
|---|
| Page | 835-842 |
|---|
| Year/Month | 1998/11 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」神経芽細胞腫の病期分類のために有用な123I-Metaiodobenzylguanidine(以下MIBG)シンチグラフィの撮像方法について検討した. 小児神経芽細胞腫19症例の加療前に123I-MIBGシンチグラフィを施行した. シンチグラムは静注6時間後と24時間後にそれぞれ全身像と, 躯幹部planar像, SPECT像を撮像し, 集積を視覚的に評価し, CT, MRIや, 骨シンチグラフィの所見と比較した. 原発巣には全例でMIBGの集積が認められ, リンパ節転移巣は9例中, 顕微鏡的転移巣であった1例を除いた8例で集積を確認できた. 原発巣, リンパ節転移の広がりを正確に評価するためには24時間後のSPECTが最も優れていた. 骨, 骨髄の転移巣に関しては123I-MIBGの6時間像にて24時間像よりも多数の病変が検出され, MIBGは骨シンチよりも多数で広範囲の異常集積を呈した. 神経芽細胞腫のより多数の病変を検出するために, 123I-MIBGシンチグラフィは, 静注後6時間前後の比較的早期の全身像と24時間前後の後期の躯幹部SPECTを撮像することが有用であると考えられた. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Neuroblastoma, 123I-MIBG scintigraphy, Staging. |
|---|
| English |
|---|
| Title | 123I-Metaiodobenzylguanidine (MIBG) Scintigraphy for the Staging of Neuroblastoma |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Chio OKUYAMA, Yo USHIJIMA, Hiroki SUGIHARA, Shigeyuki OKITSU, Tomoho MAEDA |
|---|
| Authors(kana) | |
|---|
| Organization | Department of Radiology, Kyoto Prefectural University of Medicine |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 35 |
|---|
| Number | 9 |
|---|
| Page | 835-842 |
|---|
| Year/Month | 1998/11 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | Nineteen children with neuroblastoma (aged 2w.-7y.o.) were studied to evaluate the optimal scan conditions for Iodine-123-Metaiodobenzylguanidine (MIBG) scintigraphy for accurate staging at the time of diagnosis. Six and 24 hours after an injection of 123I-MIBG, whole body image and truncal spot and SPECT images were obtained. Compared with other studies (CT or MRI and bone scintigraphy), each 123I-MIBG image was evaluated visually to investigate which image can demonstrate the extent of neuroblastoma most exactly. MIBG images demonstrated primary tumors in all patients, and metastatic lymphadenopathy in 8 of 9 patients. Twenty-four hour SPECT images gave us the most detailed information about the extent of abnormal accumulation. As to bone and bone marrow lesions, 6 hour images were superior to 24 hour images in detectability. Moreover, MIBG showed many more lesions and more extended accumulation than the hone scan. 123I-MIBG scintigraphy was very useful in detecting neuroblastomas. In order to get the most valuable information, both delayed SPECT and early whole body planar images should he obtained. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Neuroblastoma, 123I-MIBG scintigraphy, Staging. |
|---|