| Japanese |
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| Title | 脳核医学診断用自動ROI設定システムの動物PET実験への応用 |
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| Subtitle | 技術報告 |
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| Authors | 久下裕司*, 赤井信夫*, 田村浩司*, 山田学**, 谷崎直昭**, 橋本忠俊***, 今西三明***, 塩見美江***, 石田良雄****, 橋本直人* |
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| Organization | *生体機能研究所, **住友重機械工業, ***武田薬品工業, ****国立循環器病センター |
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| Journal | 核医学 |
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| Volume | 35 |
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| Number | 8 |
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| Page | 733-740 |
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| Year/Month | 1998/10 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 脳核医学診断画像の弾性モデルに基づく関心領域(ROI)自動設定システム(ProASSIST)の動物実験への応用を試みた. 本システムに, イヌ脳セグメントマップを組み込み, "動物用"ProASSISTを作成した. 今回, このシステムを正常および局所脳虚血イヌを用いたPET脳血流量, 糖代謝率測定に応用し, ROI設定の操作性, およびROI値について従来のマニュアル法と比較検討した. ProASSISTでは半自動的に輪郭線が設定される. この輪郭線の設定において, 半数のスライス(8/16スライス)でマニュアル修正が必要であった. しかし, 1スライスあたりの操作時間はこの修正時間を含めても従来のマニュアル法の場合より短かった. ProASSIST法により得られたROI値は, マニュアル法の場合と同等であった. これらの結果から, 本システムは, その操作性が良好であること, 上記実験系への応用が可能であることが示された. また, 本システムでは, 解剖学的基準の設定以外は自動的に行われるため, マニュアル法に比べて, より客観的な解析が可能であると考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | PET, Dog brain, ROI, Elastic model, Image processing |
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| English |
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| Title | Application of a Semi-automatic ROI Setting System for Brain PET Images to Animal PET Studies |
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| Authors | Yuji KUGE*, Nobuo AKAI*, Koji TAMURA*, Manabu YAMADA**, Naoaki TANIZAKI**, Tadatoshi HASHIMOTO***, Mitsuaki IMANISHI***, Mie SHIOMI***, Yoshio ISHIDA****, Naoto HASHIMOTO* |
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| Authors(kana) | |
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| Organization | *Institute for Biofunctional Research, Ltd., **Sumitomo Heavy Industries, Ltd., ***Takeda Chemical Industries, Ltd., ****National Cardiovascular Center |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 35 |
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| Number | 8 |
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| Page | 733-740 |
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| Year/Month | 1998/10 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] ProASSIST, a semi-automatic ROI (region of interest) setting system for human brain PET images, has been modified for use with the canine brain, and the performance of the obtained system was evaluated by comparing the operational simplicity for ROI setting and the consistency of ROI values obtained with those by a conventional manual procedure. Namely, we created segment maps for the canine brain by making reference to the coronal section atlas of the canine brain by Lim et al., and incorporated them into the ProASSIST system. For the performance test, CBF (cerebral blood flow) and CMRglc (cerebral metabolic rate in glucose) images in dogs with or without focal cerebral ischemia were used. In ProASSIST, brain contours were defined semi-automatically. In the ROI analysis of the test image, manual modification of the contour was necessary in half cases examined (8/16). However, the operation was rather simple so that the operation time per one brain section was significantly shorter than that in the manual operation. The ROI values determined by the system were comparable with those by the manual procedure, confirming the applicability of the system to these animal studies. The use of the system like the present one would also merit the more objective data acquisition for the quantitative ROI analysis, because no manual procedure except for some specifications of the anatomical features is required for ROI setting. |
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| Practice | Clinical medicine |
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| Keywords | PET, Dog brain, ROI, Elastic model, Image processing |
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