| Japanese |
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| Title | Alzheimer病におけるHMPAOとECDの乖離に関する検討 - 集積機序は病態に依存する? - |
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| Subtitle | 原著 |
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| Authors | 駒谷昭夫*, 菅井幸雄*, 渡邉奈美*, 山口昂一*, 川勝忍** |
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| Organization | *山形大学医学部放射線科, **山形大学医学部精神神経科 |
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| Journal | 核医学 |
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| Volume | 35 |
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| Number | 8 |
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| Page | 715-720 |
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| Year/Month | 1998/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 アルツハイマー病(AD)の低下域描出における99mTc-HMPAOと99mTc-ECDの乖離とその原因について検討した. 133XerCBF SPECTで臨床的に妥当な低血流域があり, 同時期にHMPAOとECD SPECTが施行されたAD14例, 虚血性病変(CID)31例について, 所見の乖離パターンおよびXeとの相関を病態別に対比した. CID群ではECD, HMPAO共にXeと比べ軽・中度の血流低下を検出しにくく, 特にX-CT上無所見例では検出できなかった. AD群ではECDとXeの血流低下は良好に相関したが, HMPAOは血流低下を検出しにくく, ECDとHMPAOの分布は明らかに異なった. このECDとHMPAOの乖離は, 停滞機序による. AD群では, ECD停滞機序に関与するエステラーゼの活性がHMPAOの停滞に関与するグルタチオンより著明に低下したためと考えられた. ECDとHMPAOの集積低下は, 血流低下より脳内停滞機序の障害程度に直接的に依存し, この障害程度はADやCID等の病態にも依存すると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Regional cerebral blood flow, Alzheimer's disease, 133Xe, 99mTc-ECD, 99mTc-HMPAO |
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| English |
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| Title | Discrepancy between 99mTc-HMPAO and 99mTc-ECD in Alzheimer's Disease : Does the Retention Mechanism Depend on the Disease? |
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| Authors | Akio KOMATANI*, Yukio SUGAI*, Nami WATANABE*, Koichi YAMAGUCHI*, Shinobu KAWAKATSU** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Neuropsychiatry, Yamagata University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 35 |
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| Number | 8 |
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| Page | 715-720 |
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| Year/Month | 1998/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The discrepancy between 99mTc-hexamethyl-propyleneamine oxime (HMPAO) and 99mTc-ethyl cysteinate dimer (ECD) in Alzheimer's disease (AD) was investigated and compared with in cerebral ischemic disease (CID). The subjects were fourteen AD and thirty-one CID patients with clinically reasonable rCBF reduced lesion on 133Xe SPECT. The subjects did not include the cases of acute and subacute CID. These SPECT were performed within two weeks by ring-type dynamic SPECT (HEADTOME, Shimadzu, Japan). In the CID group, both of HMPAO and ECD SPECT could hardly detect the mildly reduced rCBF lesion on 133Xe SPECT but normal on X-CT. In the case of AD group, the rCBF-reduced lesion on 133Xe SPECT could be detected well by ECD SPECT, but the HMPAO hardly detected the reduced lesion. This discrepancy between HMPAO and ECD may be due to the difference of the retention mechanism. In the case of AD, the injury of esterase activity that participates with the ECD retention may he more notable than that of glutathione activity for the HMPAO retention. These results suggest that the reduction of ECD or HMPAO density depends directly on the insufficiency of retention mechanism rather than the rCBF reduction. And the insufficiency of this retention mechanism depends on also type of the disease i.e. AD or CID. |
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| Practice | Clinical medicine |
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| Keywords | Regional cerebral blood flow, Alzheimer's disease, 133Xe, 99mTc-ECD, 99mTc-HMPAO |
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