| Japanese |
|---|
| Title | 99mTc-ECD SPECTを用いた3-コンパートメントモデルに基づく新しい脳血流測定法 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 小田野行男*, 大久保真樹**, 野口栄吉*, 大滝広雄*, 柴木充朗*, 土橋幸夫* |
|---|
| Authors(kana) | |
|---|
| Organization | *新潟大学医学部放射線科, **新潟大学医療技術短期大学部診療放射線技術学科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 35 |
|---|
| Number | 8 |
|---|
| Page | 697-703 |
|---|
| Year/Month | 1998/10 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」 99MTc-ECDの3-コンパートメントモデルに基づく新しい脳血流測定法を開発した. 1回SPECTと入力関数積分値の測定により求められる値を脳血流量を反映するパラメータと考えてbrain fractionation index(BFI)と定義し, これを用いて脳血流を精度よく測定する方法である. 脳梗塞など12例を対象に, dynamic SPECTと頻回動脈採血から得たデータを解析して, BFIを測定する最適時刻を決定した. BFIと133Xe吸入法SPECTで求めた脳血流との関係を調べ, 指数関数にあてはまるような回帰曲線を求めたところ, 良好な相関が得られた(r=0.903). この指数関数を標準的なBFI-CBF回帰式として設定した. 新たな7例を対象にBFIを測定して, この回帰式から脳血流を算出し, 133Xe吸入法SPECTで得られた脳血流と比較した. その結果, 良好な相関(r=0.854)が得られ, 回帰直線の傾きは1(=0.991)に近く, 99mTc-ECDの欠点である高血流域の過小評価は見られなかった. 本法は, 大視野ガンマカメラのみならず通常のSPECT装置にも適用でき, 汎用性のある有用な脳血流測定法である. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | 99mTc-ECD, SPECT, rCBF measurement, Three-compartment model, Graphical analysis |
|---|
| English |
|---|
| Title | Quantification of Cerebral Blood Flow with 99mTc-ECD SPECT Based on a 3-Compartment Model |
|---|
| Subtitle | |
|---|
| Authors | Ikuo ODANO*, Masaki OHKUBO**, Eikichi NOGUCHI*, Hiro OHTAKI*, Mitsurou SHIBAKI*, Sachio DOBASHI* |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiology, Niigata University School of Medicine, **Department of Radiological Technology, College of Biomedical Technology, Niigata University |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 35 |
|---|
| Number | 8 |
|---|
| Page | 697-703 |
|---|
| Year/Month | 1998/10 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] In the present study we developed a method for quantifying regional cerebral blood flow (rCBF) using 99mTc-ECD SPECT based on a 3-compartment model. The dynamic SPECT scanning and sequential sampling of arterial blood were performed on 12 subjects with cerebrovascular diseases and etc. We defined brain fractionation index (BFI) as a parameter of rCBF, which was obtained from a single SPECT data and arterial input. The relationship between the values of BFI and rCBF obtained by the 133Xe inhalation method was analyzed by approximation with exponential function. In this method, rCBF was calculated from the values of BFI using the inverse function of the exponential function as a regression curve. The method was applied seven other patients with cerebrovascular diseases and the values of rCBF were compared with those obtained by the 133Xe inhalation method. We observed a good correlation (r=0.854), and the inclination was approximately 1. This method can be applied to not only large field SPECT cameras but also conventional SPECT cameras. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | 99mTc-ECD, SPECT, rCBF measurement, Three-compartment model, Graphical analysis |
|---|