Japanese
Title123I-IMPシンチグラフィが診断に有用であった脈絡膜悪性黒色腫の一例
Subtitle症例報告
Authors小竹文雄*, 河西昌幸*, 石井巌*, 赤田壮市*, 柿崎大*, 阿部公彦*
Authors(kana)
Organization*東京医科大学放射線医学教室
Journal核医学
Volume35
Number6
Page427-433
Year/Month1998/7
Article報告
Publisher日本核医学会
Abstract「要旨」123I-IMPシンチグラフィが診断に有用であった脈絡膜悪性黒色腫の1例を経験したのでここに報告した. 症例は62歳の男性で3年前からの左眼視力低下を主訴に来院. CTでは左眼球内の視神経乳頭耳側寄りに円弧状の高吸収域を認めた. 腫瘤はMRIのT1強調像で大部分は低信号を呈しており, 中心部には一部高信号域も認められ, T2強調像では均一で強い低信号を呈していた. CTやMRIからは血腫や出血を伴った血管性腫瘍との鑑別が困難であった. 123I-IMPシンチグラフィ後期像では左眼球ほぼ全体に相当する領域に著明な高集積を認めたため悪性黒色腫の診断のもとに左眼球摘出術が施行された. 病理組織像では強膜や眼球外渦静脈周囲にも浸潤していたが, CTやMRIからは評価できなかった. 123I-IMPシンチグラフィは脈絡膜悪性黒色腫の質的診断のみでなく, 進展範囲の把握にも有用であった.
Practice臨床医学:一般
KeywordsChoroidal malignant melanoma, N-isopropyl-p-[123I]-iodoamphetamine, MRI
English
TitleA Case of Choroidal Malignant Melanoma in which 123I-IMP Scintigraphy was Useful for Diagnosis
Subtitle
AuthorsFumio KOTAKE, Masayuki KAWANISHI, Iwao ISHII, Souichi AKATA, Dai KAKIZAKI, Kimihiko ABE
Authors(kana)
OrganizationDepartment of Radiology, Tokyo Medical University
JournalThe Japanese Journal of nuclear medicine
Volume35
Number6
Page427-433
Year/Month1998/7
ArticleReport
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractA case of choroidal malignant melanoma in which N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) scintigraphy was useful for diagnosis is reported. A 62-year-old man first visited our hospital 3 years ago complaining of decreases in left eyesight. CT showed a tumor with an arcuate high attenuation area on the aural side of the optic disk in the left eye. A crescent high attenuation area, evidence of retinal detachment, was also observed on the nasal side of the optic disk. T1-weighted MR images showed low signal intensity in most of the tumor and a high signal intensity area was seen in the center. T2-weighted MR images showed homogeneous and marked low signal intensity area. Differentiation from a hematoma or a vascular tumor associated with bleeding was impossible based on CT and MRI. However, because late-phase images obtained on 123I-IMP scintigraphy showed marked high accumulation in an area corresponding to almost the entire left eye, left eye enucleation was undertaken under a diagnosis of malignant melanoma. Histopathologic examinations showed tumor growth mainly in the subretinal area. The melanin content of the tumor was high in the periphery and relatively low in the center. Infiltration was observed into the sclera and around the vortex vein outside the eyeball, but this change could not be detected by CT or MRI. 123I-IMP scintigraphy was useful not only for qualitative diagnosis of choroidal malignant melanoma, but for the determination of the extent of the lesion as well.
PracticeClinical medicine
KeywordsChoroidal malignant melanoma, N-isopropyl-p-[123I]-iodoamphetamine, MRI

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