| Japanese |
|---|
| Title | 1点動脈採血と 123I-IMP microsphere model による簡便な局所脳血流量測定法 - 全脳カウント比を用いた1点動脈採血全血カウントの持続動脈採血オクタノール抽出後カウントへの補正 - |
|---|
| Subtitle | 原著 |
|---|
| Authors | 牧野憲一*, 増田安彦**, 後藤聰* |
|---|
| Authors(kana) | |
|---|
| Organization | *旭川赤十字病院脳神経外科, **旭川赤十字病院放射線科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 35 |
|---|
| Number | 6 |
|---|
| Page | 405-412 |
|---|
| Year/Month | 1998/7 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) と microsphere model を用いての局所脳血流量測定法を持続動脈採血を行う代わりに一点動脈採血を用いる方法が考案されているが, この精度を上げるため SPECT planar image から得られた5分と29分の全脳カウント比を利用する方法を考案した. 189例の脳血管障害患者を対象とした. 123I-IMP 222MBqを急速静注し, 同時に左上腕動脈より5分間の持続動脈採血を行い, その直後に1点動脈採血を行った. 123I-IMP SPECT は123I-IMP投与後4分30秒から5分30秒までの1分間 planar image を収集し, 6分30秒より20分間のSPECT画像収集を行った. さらにその後29分を中心として1分間の planar image 収集を行った. 1点動脈採血全血カウントと持続動脈採血オクタノール抽出後のカウント間には有意の相関が存在していた(r=0.87, p<0.001). 補正は以下の通り行った. 持続動脈採血オクタノール抽出後のカウント(OC)と5分1点動脈採血全血カウント(TC5)との比を5/29比(Cn)と対比させ相関式を求めた. 両者の間には有意の相関が存在した(r=0.72, p<0.001). その相関式から OC/TC5 = 0.390968×Cn - 0.08924 の関係が示された. この相関式をもとに理論上の持続動脈採血オクタノール抽出後カウント(COC)を求めた. COC = TC5×(0.390968×Cn - 0.08924) この式より得られた値と持続動脈採血オクタノール抽出後のカウント実測値とはきわめて良好な相関を示した(r=0.94, p<0.001). 相関係数は補正前のr=0.87からr=0.94へと改善した. 23例で行った6分から10分での1点動脈採血でも5分で行ったのと同様に5/29比を用いることにより相関係数が改善した. 5分と29分の全脳カウント比を利用して一点動脈血全血カウントを補正することにより高い精度で持続動脈採血オクタノール抽出後のカウントに置き換えることが可能となる. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Cerebral blood flow, 123I-IMP, Microsphere model, SPECT |
|---|
| English |
|---|
| Title | Measurement of Regional Cerebral Blood Flow Using One-Point Arterial Blood Sampling and Microsphere Model with 123I-IMP : Correction of One-Point Arterial Sampling Count by Whole Brain Count Ratio |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Kenichi MAKINO*, Yasuhiko MASUDA**, Satoshi GOTOH* |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Neurosurgery, **Department of Radiology, Asahikawa Red Cross Hospital |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 35 |
|---|
| Number | 6 |
|---|
| Page | 405-412 |
|---|
| Year/Month | 1998/7 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | A correction method was proposed for measurement of the regional cerebral blood flow using one-point arterial blood sampling and a microsphere model with N-isopropyl-p-(123I)iodoamphetamine (123I-IMP). Instead of using continuous arterial blood sampling octanol-extracted counts, one-point arterial sampling whole blood counts corrected by the whole brain count ratio using 1-minute planar SPECT images were employed. The experimental subjects were 189 patients with cerebrovascular disorders. 123I-IMP, 222 MBq, was administered by intravenous infusion. Continuous arterial blood sampling was carried out for 5 minutes, and arterial blood was also sampled once at 5 minutes after 123I-IMP administration. Then the whole blood count of the one-point arterial sampling was compared with the octanol-extracted count of the continuous arterial sampling. A positive correlation was found between the two values (r = 0.87, p < 0.001). The correction method was carried out by calculation as follows. The ratio of the continuous sampling octanol-extracted count (OC) to the one-point sampling whole blood count (TC5) was compared with the whole brain count ratio (5 : 29 ratio, Cn) using 1-minute planar SPECT images, centering on 5 and 29 minutes after 123I-IMP administration. Correlation was found between the two values (r = 0.72, p < 0.001). The following relationship was shown from the correlation equation. OC/TC5 = 0.390969×Cn - 0.08924. Based on this correlation equation, we calculated the theoretical continuous arterial sampling octanol-extracted count (COC). COC = TC5×(0.390969×Cn - 0.08924). There was good correlation between the value calculated with this equation and the actually measured value (r = 0.94, p < 0.001). The coefficient improved to r = 0.94 from the r = 0.87 obtained before using the 5 : 29 ratio for correction. For 23 of these 189 cases, another one-point arterial sampling was carried out at 6, 7, 8, 9 and 10 minutes after the administration of 123I-IMP. The correlation coefficient was also improved for these other point samplings when this correction method using the 5 : 29 ratio was applied. It was concluded that it is possible to obtain highly accurate input functions, i.e., calculated continuous arterial sampling octanol-extracted counts, using one-point arterial sampling whole blood counts by performing correction using the 5 : 29 ratio. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Cerebral blood flow, 123I-IMP, Microsphere model, SPECT |
|---|