Japanese
Title心電図同期心筋SPECTにおける心機能解析の変法 : Functional G-maps の検討
Subtitle原著
Authors小野口昌久*1, 丸野廣大*2, 村田啓*3, 森一晃*2, 外山比南子*4, 吉岡克則*5, 高山輝彦*1, 煎本正博*6, 片山仁*6
Authors(kana)
Organization*1金沢大学医学部保健学科, *2虎の門病院核医学, *3放射線医学総合研究所重粒子治療センター, *4東京都老人総合研究所ポジトロン医学研究部, *5GE横河メディカルシステム, *6順天堂大学医学部放射線科
Journal核医学
Volume35
Number6
Page385-393
Year/Month1998/7
Article原著
Publisher日本核医学会
Abstract「要旨」心電図同期心筋SPECTを用いて心機能を正確に評価するために, 心機能解析の変法(Functional G-maps)を試みた. 安静時に99mTc-tetrofosmin 1,110MBqを投与し, その1時間後に1心拍を12分割して Gated SPECT を収集した. 得られた短軸像を, 最大収縮末期から最大拡張末期まで各10スライスにスライス厚補正して再構築した. これらの各短軸像を40領域に分割し, トータルカウントを用いて作成した時間放射能曲線を2次逆フーリエ級数で近似し, 合計400領域を自動解析して, 収縮末期カウント(Max), 拡張末期カウント(Min), カウント増加率(%CI), 摂取率(Uptake)のほかに, 新たに最大収縮速度(PCR), 最大拡張速度(PDR), 駆出時間(CT)を算出した. これらの指標値を用いて機能画像を作成した. 正常例では%Maxは前壁から中隔にかけて値が高く, %Minでは心尖部と側壁で高値を示した. %CIと%PCRはほぼ同様に中隔, 前壁, 下壁で高値であったが, %PDRは側壁, 下壁が他の3領域に比べ若干低値を示した. 本システムによって新たな指標が得られ, 心筋血流の評価と同時に心機能を視覚的に評価することができ, 臨床応用の可能性が示唆された.
Practice臨床医学：一般
KeywordsECG gated SPECT, Cardiac functional analysis, 99mTc-tetrofosmin, Functional G-maps
English
TitleA Modified Method of Cardiac Functional Analysis for ECG Gated SPECT : Study of Functional G-Maps
SubtitleOriginal Articles
AuthorsMasahisa ONOGUCHI*1, Hirotaka MARUNO*2, Hajime MURATA*3, Kazuaki MORI*2, Hinako TOYAMA*4, Katsunori YOSHIOKA*5, Teruhiko TAKAYAMA*1, Masahiro IRIMOTO*6, Hitoshi KATAYAMA*6
Authors(kana)
Organization*1School of Health Sciences, Faculty of Medicine, Kanazawa University, *2Division of Nuclear Medicine, Toranomon Hospital, *3National Institute of Radiological Sciences, *4Tokyo Metropolitan Institute of Gerontology, *5GE Yokogawa Medical Systems, Ltd., *6Department of Radiology, Faculty of Medicine, Juntendo University
JournalThe Japanese Journal of nuclear medicine
Volume35
Number6
Page385-393
Year/Month1998/7
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractTo evaluate the cardiac function accurately using ECG gated SPECT images, we performed a modified method of cardiac functional analysis (Functional G-maps). One hour after the intravenous injection of 1,110 MBq of 99mTc-tetrofosmin, gated SPECT data was acquired dividing a cardiac cycle into 12 frames. Every short-axis images were usually reconstructed using first 11 of 12 frames. The reconstruction of these images was repeated performing slice thickness correction. Because the apex-to-base length is different at any frame during a cardiac cycle, 10 slices of short-axis images were obtained with the same thickness for each frame. Subsequently each short-axis image was divided by 40 radii, and the time activity curve was generated from the total counts included in each segment plus both neighboring segments. Afterwards the curve fitting was performed using the second reverse Fourier function. From fitted curves and their differentials, we estimated a variety of parameters including Max (End-systolic count), Min (End-diastolic count), %CI (Percent count increase), Uptake, PCR (Peak contraction rate), PDR (Peak distention rate) and CT (Contraction time). In 5 normal subjects, %Max was greater in the anterior and septal regions, whereas %Min was greater in the apex and lateral regions. %CI and %PCR were similarly greater in the septal, anterior and inferior regions. On the other hand, %PDR in the lateral or inferior region was lower than the values in the other regions. In conclusion, this modified method is expected to be useful for accurate assessment of regional cardiac function and myocardial perfusion.
PracticeClinical medicine
KeywordsECG gated SPECT, Cardiac functional analysis, 99mTc-tetrofosmin, Functional G-maps

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