| Japanese |
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| Title | 123I-BMIPP心筋SPECTの臨床的意義 |
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| Subtitle | 総説 |
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| Authors | 山崎純一* |
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| Authors(kana) | |
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| Organization | *東邦大学医学部内科学第一講座 |
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| Journal | 核医学 |
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| Volume | 35 |
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| Number | 6 |
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| Page | 367-373 |
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| Year/Month | 1998/7 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」123I-BMIPPはβ位にメチル基を有する側鎖脂肪酸で, β酸化を受けにくく心筋内に長く留まるため, 心筋SPECTに適した代謝イメージング製剤である. BMIPPは血中から心筋細胞内に取り込まれた後, 主にトリグリセライドなどの貯蔵型脂肪酸として心筋内に留まるが, 病態により異なった挙動を示す. 通常BMIPP静注後, 初期像(20分後)を撮像するが, 遅延像(4時間後)も撮像することにより, 心筋梗塞や肥大型心筋症例では washout や fill in を認めることがある. またTlとBMIPPの乖離所見は stunned myocardium の診断や重症度評価に有用である. しかし, BMIPPの心筋内挙動については不明の点もあり, 各種心疾患症例の蓄積により, 臨床的意義が解明されるものと思われる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-BMIPP, Myocardial SPECT, Fatty acid metabolism |
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| English |
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| Title | Clinical Significance of 123I-BMIPP Myocardial SPECT |
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| Subtitle | Reviews |
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| Authors | Junichi YAMAZAKI |
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| Authors(kana) | |
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| Organization | First Department of Internal Medicine, Toho University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 35 |
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| Number | 6 |
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| Page | 367-373 |
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| Year/Month | 1998/7 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | 123I-BMIPP is a radioiodinated branched chain fatty acid analog, showing high accumulation as well as prolonged retention in the myocardium. Therefore, it is used as a metabolic imaging agent suitable for myocardial SPECT. After 123I-BMIPP is taken in the myocardium, it remains there mainly as a storage type fatty acid of triglyceride, and it shows different behavior by the stage of cardiac disease. Usually, we evaluate metabolic findings by early imaging (20 minutes) after intravenous injection of 123I-BMIPP, however, some times washout or fill in are seen in the case of myocardial infarction or hypertrophic cardiomyopathy by delayed imaging (after 4 hours). The mismatch of 201TlCl and 123I-BMIPP are useful for the diagnosis of stunned myocardium or evaluation of prognosis. However, behavior of 123I-BMIPP in myocardium is known still not completely. Therefore clinical significance of this examination is thought to be clarified by the stock of cases of various heart diseases. |
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| Practice | Clinical medicine |
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| Keywords | 123I-BMIPP, Myocardial SPECT, Fatty acid metabolism |
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