Japanese
Title123I-IMPを用いた非侵襲的マイクロスフェア法による局所脳血流量測定 - Fractional Uptake 変法と持続動脈採血法との比較 -
Subtitle原著
Authors中野正剛*,*****, 松田博史*, 谷崎洋*, 小川雅文**, 宮崎吉春***, 米倉義晴****
Authors(kana)
Organization*国立精神・神経センター武蔵病院放射線診療部, **国立精神・神経センター神経内科, ***公立能登総合病院中央放射線部, ****福井医科大学高エネルギー医学研究センター, *****東京医科大学老年科
Journal核医学
Volume35
Number4
Page209-218
Year/Month1998/4
Article原著
Publisher日本核医学会
Abstract「要旨」米倉らの開発した N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) を用いた非侵襲的マイクロスフェア法による局所脳血流測定を, 神経疾患を有する患者10例に対して施行した. この方法により得られた脳血流値を, 同時に施行した宮崎らの開発した Fractional Uptake (FU) 法において算出心拍出量を用いるFU変法および従来の持続動脈採血法により得られた脳血流値と比較した. 比較に際しては, SPECT像における再構成値から局所脳血流量への換算値を CBF factor と命名して検討した. 持続動脈採血法と非侵襲的マイクロスフェア法による CBF factor は, r=0.962 (p<0.001) ときわめて高い有意の相関が得られた. 非侵襲的マイクロスフェア法により得られた CBF factor は持続動脈採血法のそれに比べ平均で2.7%の高値にとどまった. 一方, FU変法と持続動脈採血法は, 前者において全脳合計SPECTカウント算出の際の閾値10%でr=0.811, 閾値30%でr=0.798の有意の相関を得た. しかし, 前者は後者に比べ, 閾値10%で平均31.4%, 閾値30%で平均62.3%, CBF factor を過大評価した. 結論として, 非侵襲的マイクロスフェア法は簡便な局所脳血流定量法として日常臨床上有用であると考えられた.
Practice臨床医学：一般
Keywords123I-IMP, Cerebral blood flow, SPECT, Cardiac output, Fractional uptake
English
TitleRegional Cerebral Blood Flow Measurements by a Noninvasive Microsphere Method Using 123I-IMP : Comparison with the Modified Fractional Uptake Method and the Continuous Arterial Blood Sampling Method
SubtitleOriginal Articles
AuthorsSeigo NAKANO*,*****, Hiroshi MATSUDA*, Hiroshi TANIZAKI*, Masafumi OGAWA**, Yoshiharu MIYAZAKI***, Yoshiharu YONEKURA****
Authors(kana)
Organization*Division of Radiology, **Department of Neurology, National Center Hospital for Mental, Nervous, and Muscular disorders, NCNP, ***Central Radiology Division, Noto General Hospital, ****Biomedical Imaging Research Center, Fukui Medical School, *****Department of Geriatric Medicine, Tokyo Medical College
JournalThe Japanese Journal of nuclear medicine
Volume35
Number4
Page209-218
Year/Month1998/4
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractA noninvasive microsphere method using N-isopropyl-p-[123I]iodoamphetamine (123I-IMP), developed by Yonekura et al., was performed in 10 patients with neurological diseases to quantify regional cerebral blood flow (rCBF). Regional CBF values by this method were compared with rCBF values simultaneously estimated from both the modified fractional uptake (FU) method using cardiac output developed by Miyazaki et al. and the conventional method with continuous arterial blood sampling. In comparison, we designated the factor which converted raw SPECT voxel counts to rCBF values as a CBF factor. A highly significant correlation (r = 0.962, p < 0.001) was obtained in the CBF factor s between the present method and the continuous arterial blood sampling method. The CBF factors by the present method were only 2.7% higher on the average than those by the continuous arterial blood sampling method. There were significant correlation (r = 0.811 and r = 0.798, p < 0.001) in the CBF factor between modified FU method (threshold for estimating total brain SPECT counts; 10% and 30% respectively) and the continuous arterial blood sampling method. However, the CBF factors of the modified FU method showed 31.4% and 62.3% higher on the average (threshold; 10% and 30% respectively) than those by the continuous arterial blood sampling method. In conclusion, this newly developed method for rCBF measurements was considered to be useful for routine clinical studies without any blood sampling.
PracticeClinical medicine
Keywords123I-IMP, Cerebral blood flow, SPECT, Cardiac output, Fractional uptake

【全文PDF】