| Japanese |
|---|
| Title | Diamox 負荷時における 123I-IMP SPECT を用いたマイクロスフェアモデルに基づく局所脳血流定量法の精度の検討 |
|---|
| Subtitle | 短報 |
|---|
| Authors | 大久保真樹*, 小田野行男**, 野口栄吉**, 大滝広雄**, 柴木充朗**, 土橋幸夫**, 横井孝司*** |
|---|
| Authors(kana) | |
|---|
| Organization | *新潟大学医療技術短期大学部診療放射線技術学科, **新潟大学医学部放射線科, ***島津製作所医用技術部 |
|---|
| Journal | 核医学 |
|---|
| Volume | 35 |
|---|
| Number | 3 |
|---|
| Page | 147-151 |
|---|
| Year/Month | 1998/3 |
|---|
| Article | 報告 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」Diamox 負荷時における 123I-IMP SPECT を用いたマイクロスフェアモデルに基づく局所脳血流(rCBF)定量法の精度を調べた. 検討した定量法は, IMP静注5分後のSPECT撮像と持続動脈採血を行う超早期マイクロスフェア法と, 静注30分後のSPECT撮像と1点動脈採血を行う早期マイクロスフェア法である. 5名の被検者において, Diamox 投与10分後にIMPを静注し直後からダイナミックSPECT撮像と頻回動脈採血を行い, 2コンパートメントモデル解析によってrCBFを算出した. 超早期マイクロスフェア法と早期マイクロスフェア法で求めたrCBFは, いずれも2コンパートメントモデル解析による値と高い相関を示し(r=0.982, 0.930), 偏りはほとんどみられなかった. マイクロスフェアモデルに基づく定量法は, 安静時のみならず Diamox 負荷時においても適用可能であることが確認された. 特に, 1点採血法による早期マイクロスフェア法は侵襲性が低く簡便で, より臨床に適する方法と考えられる. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | 123I-IMP, SPECT, rCBF, Acetazolamide, Microsphere model |
|---|
| English |
|---|
| Title | A Study on Accuracy of rCBF Measurements Loaded with Acetazolamide Based on the Microsphere Model Using Iodine-123-IMP SPECT |
|---|
| Subtitle | Short Communication |
|---|
| Authors | Masaki OHKUBO*, Ikuo ODANO**, Eikichi NOGUCHI**, Hiroh OHTAKI**, Mitsuroh SHIBAKI**, Yukio DOBASHI**, Takashi YOKOI*** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiological Technology, College of Biomedical Technology, Niigata University, **Department of Radiology, Niigata University School of Medicine, ***Department of Research for Medical Systems, Shimadzu Corporation |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 35 |
|---|
| Number | 3 |
|---|
| Page | 147-151 |
|---|
| Year/Month | 1998/3 |
|---|
| Article | Report |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | We studied the accuracy of the method for measuring regional cerebral blood flow (rCBF) loaded with acetazolamide based on the microsphere model using iodine-123-IMP (IMP) SPECT. Two methods were examined, the super-early microsphere method with continuous withdrawal of arterial blood using the SPECT image obtained 5 min after tracer injection and the early microsphere method with one-point arterial sampling using the SPECT image obtained 30 min postinjection. On five subjects, after acetazolamide administration we measured rCBF by the analysis based on the two-compartment model using the data derived from dynamic SPECT scans and the sequential arterial blood sampling after IMP injection. Values of rCBF obtained by both super-early microsphere method and early microsphere method were significantly correlated with those obtained by the two-compartment model analysis (r = 0.982, 0.930, respectively). We conclude that it is possible to use the method based on the microsphere model in measuring rCBF loaded with acetazolamide. The early microsphere method with one-point sampling should be used clinically because of its simplicity and less-invasiveness. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | 123I-IMP, SPECT, rCBF, Acetazolamide, Microsphere model |
|---|