| Japanese |
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| Title | 脳血流シンチグラム製剤の集積機序 |
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| Subtitle | 総説 |
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| Authors | 井上優介* |
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| Organization | *東京大学医科学研究所放射線科 |
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| Journal | 核医学 |
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| Volume | 35 |
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| Number | 2 |
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| Page | 93-97 |
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| Year/Month | 1998/2 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」現在, ケミカル・マイクロスフェアと呼ばれるトレーサが, 脳血流シンチグラム製剤として広く用いられている. これらの薬剤は, 静注されてから動脈血にのって脳に運ばれ, 正常の血液脳関門を高率に通過して脳組織に入る. 脳に入ったトレーサは何らかのメカニズムで流出を阻止され, 長時間脳内に保持される. 脳血流分布に応じた集積分布が長時間保たれるため, 高画質の脳血流SPECT像を得ることができる. しかし, 純粋なマイクロスフェアと違って脳血流シンチグラム製剤の脳集積過程は複雑であり, 様々な原因で集積分布は血流分布と異なるものになり, 時にその乖離は大きくなる. ここでは, 脳血流シンチグラム製剤の集積機序について概説する. こうした知識を踏まえた上で, 使用するトレーサを選択したり, 画像を解釈することが望まれる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Cerebral blood flow, SPECT, Cerebral kinetics, Subacute infarction, Brain tumor |
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| English |
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| Title | Cerebral Kinetics of Brain Perfusion Agents |
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| Subtitle | Review |
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| Authors | Yusuke INOUE |
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| Authors(kana) | |
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| Organization | Department of Radiology, Institute of Medical Science, University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 35 |
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| Number | 2 |
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| Page | 93-97 |
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| Year/Month | 1998/2 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Radiotracers called chemical microsphere are widely accepted as brain perfusion agents. Following the intravenous administration, these drugs are transported via the artery to the brain, cross the intact blood-brain barrier, and enter the brain tissue. Once the tracer flows into the brain, the efflux of the tracer is prevented by some trapping mechanism, resulting in prolonged retention. Because the distribution of the accumulated tracer remains approximately consistent with regional cerebral blood flow for a relatively long period, high-quality SPECT images reflecting the distribution pattern of cerebral blood flow can be acquired. However, unlike true microsphere, cerebral kinetics of the brain perfusion agents is complicated, and various causes may produce discrepancy between the distributions of the tracer and blood flow. In this review, cerebral kinetics of the brain perfusion agents used commonly is discussed. The knowledge of the mechanism of brain accumulation appears to be essential to appropriately determine the tracer of choice and interpret the obtained images. |
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| Practice | Clinical medicine |
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| Keywords | Cerebral blood flow, SPECT, Cerebral kinetics, Subacute infarction, Brain tumor |
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