| Japanese |
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| Title | 標準脳座標系を用いたアルツハイマー病患者の 123I-IMP SPECT 脳血流画像の解析 - アルツハイマー型痴呆における局所脳血流低下 - |
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| Subtitle | 短報 |
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| Authors | 熊倉嘉貴*, 百瀬敏光*, 奥真也*, 大嶽達*, 西川潤一*, 佐々木康人* |
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| Organization | *東京大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 35 |
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| Number | 1 |
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| Page | 29-32 |
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| Year/Month | 1998/1 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」Friston らにより開発されたSPM95は, 脳PET画像を標準脳図譜上へ写像し, その画像を全脳平均カウントにより標準化することができる. さらに解剖学的に対応する座標上のボクセル値を群間で検定し, 算出された統計量を標準脳図譜上の座標に出力する. 今回, この手法を123I-IMP脳血流SPECT定性画像に応用し, アルツハイマー型痴呆群(17例)を正常群(9例)と比較した. その結果, 標準脳図譜上に得られた有意な血流低下領域は, 両側側頭頭頂部および帯状回後部であった. PETによる糖代謝画像などでも同様の結果が示されており, 脳血流SPECT画像の客観的評価法としてSPM95の有用性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Dementia of Alzheimer type, Regional cerebral blood flow, Single photon emission computed tomography, Statistical parametric map |
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| English |
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| Title | Analysis of Cerebral Blood Flow SPECT Imaging on Standard Brain Atlas in Patients with Dementia of Alzheimer Type |
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| Subtitle | Short Communication |
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| Authors | Yoshitaka KUMAKURA, Toshimitsu MOMOSE, Shinya OKU, Tohru OHTAKE, Junichi NISHIKAWA, Yasuhito SASAKI |
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| Authors(kana) | |
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| Organization | Department of Radiology, Faculty of Medicine, University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 35 |
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| Number | 1 |
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| Page | 29-32 |
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| Year/Month | 1998/1 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Statistical parametric map (SPM) has been developed by Friston et al. to analyze focal changes in rCBF induced by brain activation. This automated and objective approach has the potential of being applied to SPECT image data sets. This study evaluated an automated analysis of brain SPECT imaging in patients with dementia of Alzheimer type (DAT) using SPM95. Seventeen patients with clinically diagnosed moderate to severe DAT and nine normal control subjects were studied. The SPECT device used was a triple-headed rotation gamma camera GCA9300A/HG. All images were transformed into the standard anatomical space of the stereotactic brain atlas of Talairach and Tournoux, and then smoothed. Statistical analysis was made between DAT and normal control groups. SPM analysis of SPECT images revealed that the parieto-temporal areas and posterior cingulate gyrus of both cerebral hemispheres were significantly decreased in DAT patients compared to normal controls. In conclusion, SPM analysis of SPECT images proved to be useful in the evaluation of abnormal perfusion areas of demented patients. |
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| Practice | Clinical medicine |
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| Keywords | Dementia of Alzheimer type, Regional cerebral blood flow, Single photon emission computed tomography, Statistical parametric map |
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