| Japanese |
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| Title | 123I-IMP microsphere model による簡便な局所脳血流定量測定 - 全脳時間放射能曲線と一点動脈採血から得られる入力カウントの妥当性 - |
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| Subtitle | 原著 |
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| Authors | 井上武*, 藤岡弘良**, 石丸良広*, 赤宗明久*, 村瀬研也***, 棚田修二***, 池添潤平*** |
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| Authors(kana) | |
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| Organization | *松山市民病院放射線科, **松山市民病院放射線室, ***愛媛大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 35 |
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| Number | 1 |
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| Page | 15-20 |
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| Year/Month | 1998/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」123I-IMPを用いたマイクロスフェアモデルとして, 持続動脈採血の代わりに123I-IMP投与後早期の一時点で動脈血を採血し, その時点までの全脳時間放射能曲線を用いて入力カウントを推定する新しい方法を考案した. マイクロスフェアモデルが成立する123I-IMP投与後早期の全脳時間放射能曲線Cb(t)の微分曲線 dCb(t)/dt は入力関数である動脈血放射能曲線Ca(t)に相似する. これを利用し, 5分時の全脳放射能Cb(5 min)と微分値 dCb(5 min)/dt と5分時の1点動脈採血オクタノール抽出カウントCa(5 min)を用いて, Ca(t)の0〜5分の積分値である入力カウントを推定した. 本法で算出した入力カウントは持続動脈採血で得られた実測値とよく相関した. 本法は持続動脈採血法よりも簡便で侵襲性が少なく, 日常臨床において有用と考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP SPECT, One point blood sampling, Microsphere model, Regional cerebral blood flow |
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| English |
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| Title | Simplified Method to Quantitate Regional Cerebral Blood Flow by 123I-IMP Microsphere Model : Validity of Input Counts by Using the Whole Brain Time-Activity Curve and One Point Arterial Blood Sampling |
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| Subtitle | Original Articles |
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| Authors | Takeshi INOUE*, Hiroyoshi FUJIOKA*, Yoshihiro ISHIMARU*, Akihisa AKAMUNE*, Kenya MURASE**, Shuji TANADA**, Junpei IKEZOE** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Matsuyama Shimin Hospital, **Department of Radiology, Ehime University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 35 |
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| Number | 1 |
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| Page | 15-20 |
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| Year/Month | 1998/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | We developed a new microsphere method using 123I-IMP in which arterial blood is collected at one time point early after 123I-IMP injection instead of conventional continuous arterial blood sampling, and the input count is estimated using a whole brain time-activity curve until that time point. The differential curve dCb(t)/dt of the brain time-activity curve Cb(t) early after 123I-IMP injection (when the microsphere model is established) approximates the arterial time-activity curve Ca(t) as an input function. The input count as the integral value of Ca(t) at 0 - 5 min was estimated using the 5-min whole brain activity Cb(5 min) and the differential value dCb(5 min)/dt and the 5-min octanol-extracted count of arterial samples obtained at one time point Ca(5 min). The input counts calculated by this method were very closely correlated with measurement values obtained by continuous arterial sampling. This method is more convenient and less invasive than the continuous arterial sampling method. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP SPECT, One point blood sampling, Microsphere model, Regional cerebral blood flow |
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