| Japanese |
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| Title | 1回動脈採血による123I-IMPを用いた局所脳血流測定のための入力関数の積分値の推定 |
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| Subtitle | 原著 |
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| Authors | 藤岡弘良*, 村瀬研也****, 井上武**, 石丸良広**, 赤宗明久**, 山本祐司***, 棚田修二****, 池添潤平**** |
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| Authors(kana) | |
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| Organization | *松山市民病院放射線室, **松山市民病院放射線科, ***松山市民病院脳神経外科, ****愛媛大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 35 |
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| Number | 1 |
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| Page | 7-14 |
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| Year/Month | 1998/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) を静注後早期の全脳における時間放射能曲線を最小二乗法を用いて curve fitting して求めた式を微分し, さらに5分時の1点動脈採血をして求めたオクタノール抽出分画放射能で補正して, それを5分間積分することにより, マイクロスフェア法で用いられている持続動脈採血の代用法を考案した. 本法で得られた入力関数の積分値と持続動脈採血で得た入力関数の積分値との間には良好な相関が得られた(y = 1.048x - 1206, r = 0.984). また, 5分間の持続動脈採血で得た入力関数の積分値を用いて算出した脳血流量と本法で推定した入力関数の積分値を用いて算出した脳血流量との誤差は6.88±4.78%であった. 本法による入力関数の積分値の推定法は侵襲性が少なく, 簡便であり, また心肺機能や喫煙の影響を受けにくいため, ルーチン検査に有用であると考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, Cerebral blood flow, Microsphere model, Whole brain time-activity curve |
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| English |
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| Title | Estimation of Integral Value of Input Function for the Quantification of Cerebral Blood Flow with 123I-IMP Using One-Point Arterial Blood Sampling |
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| Subtitle | Original Articles |
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| Authors | Hiroyoshi FUJIOKA*, Kenya MURASE***, Takeshi INOUE*, Yoshihiro ISHIMARU*, Akihisa AKAMUNE*, Yuji YAMAMOTO**, Shuji TANADA***, Junpei IKEZOE*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Matsuyama Shimin Hospital, **Department of Neurosurgery, Matsuyama Shimin Hospital, ***Department of Radiology, Ehime University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 35 |
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| Number | 1 |
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| Page | 7-14 |
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| Year/Month | 1998/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Cerebral blood flow (CBF) has been measured using a microsphere model with octanol-extracted radioactivity counts (integral value of input function). We developed a new method estimating the integral value of input function. First, we fitted the whole brain time-activity curves early after intravenous injection of N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) by the least-squares method. Second, we differentiated this equation. Third, we calibrated it using octanol-extracted radioactivity counts of the arterial blood sampled at 5 min. Finally, we integrated it. A significant correlation was found between the integral values obtained using a new method and those obtained using the continuous arterial blood sampling data (y = 1.048x - 1206, r = 0.984). The errors between the CBF values obtained using a new method and those obtained using the 5-min continuous arterial blood sampling was 6.88 +- 4.78%. Measurement of integral values of the input function using a new method with one-point arterial blood sampling is less invasive and convenient, and is not influenced by cardiopulmonary disease or smoking. Therefore, it would be useful for the routine measurement of CBF. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, Cerebral blood flow, Microsphere model, Whole brain time-activity curve |
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