| Japanese |
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| Title | I型, II型CD36欠損症と123I-BMIPP心筋無集積について |
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| Subtitle | 原著 |
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| Authors | 渡辺賢一*, 鳥羽健**, 小川祐輔**, 相沢義房**, 田辺直仁**, 宮島静一***, 草野頼子***, 長友孝文****, 広川陽一***** |
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| Authors(kana) | |
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| Organization | *新潟薬科大学臨床薬理学, **新潟大学医学部第一内科, ***燕労災病院循環器内科, ****新潟薬科大学薬理学, *****新潟三之町病院内科 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 12 |
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| Page | 1125-1130 |
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| Year/Month | 1997/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」CD36は酸化LDL受容体として動脈硬化に関与するだけでなく, 長鎖脂肪酸輸送蛋白として脂肪酸代謝異常との関係が注目されている. 心疾患におけるCD36欠損症の頻度と123I-BMIPP心筋集積との関係を検討した. 各種心疾患で外来通院中200例からフローサイトメトリー法にてCD36を検索し, 単球と血小板の両者に欠損(I型)か, 血小板のみに欠損(II型)かを判定した. CD36欠損症24例中21例では123I-BMIPP心筋集積とを対比した. (1) CD36欠損症の頻度. I型CD36欠損症は肥大型心筋症2例, 拡張型心筋症1例, 陳旧性心筋梗塞症2例, 狭心症3例の計8例(4%)にみられた. II型CD36欠損症は肥大型心筋症3例, 拡張型心筋症1例, 心筋梗塞症1例, 狭心症8例, その他3例の計16例(8%)にみられた. (2) 123I-BMIPPとの関係. I型CD36欠損症では123I-BMIPP心筋無集積がみられたが, II型CD36欠損症では123I-BMIPPの心筋への集積がみられた. 以上から心疾患ではCD36欠損症が12%にみられ, I型CD36欠損が123I-BMIPP心筋無集積と関係する. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-BMIPP, CD36 deficiency, Long-chain fatty acids, Cardiomyopathy, Ischemic heart disease |
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| English |
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| Title | Different Patterns of 123I-BMIPP Myocardial Accumulation in Patients with Type I and II CD36 Deficiency |
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| Subtitle | Original Articles |
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| Authors | Kenichi WATANABE*, Ken TOBA**, Yusuke OGAWA**, Yoshifusa AIZAWA**, Naohito TANABE**, Seiichi MIYAJIMA***, Yoriko KUSANO***, Takafumi NAGATOMO****, Yoichi HIROKAWA***** |
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| Authors(kana) | |
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| Organization | *Department of Clinical Pharmacology, Niigata College of Pharmacy, **First Department of Medicine, Niigata University School of Medicine, ***Division of Cardiology, Tsubame Rosai Hospital, ****Department of Pharmacy, Niigata College of Pharmacy, *****Division of Internal Medicine, Niigata Sannocho Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 12 |
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| Page | 1125-1130 |
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| Year/Month | 1997/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | The CD36 molecule is a multifunctional membrane type receptor glycoprotein that reacts with thrombospondin, collagen, oxidized LDL and long-chain fatty acids (LCFA). LCFA are one of the major cardiac energy substrates, hence LCFA metabolism may have an important role in cardiac diseases. In this study, we analyzed CD36 expression in 200 patients with heart diseases [44 patients with hypertrophic cardiomyopathy (HCM), 16 with dilated cardiomyopathy (DCM), 26 with old myocardial infarction (OMI), 55 with angina pectoris (AP) and 59 with other miscellaneous heart diseases] using a flow cytometer. 123I-β-methyl-p-iodophenylpentadecanoic acid (BMIPP) myocardial accumulation was also examined in some patients. Eight patients (2 with HCM, 1 with DCM, 2 with OMI, and 3 with AP) were diagnosed as having type I CD36 deficiency (neither platelets nor monocytes expressed CD36). Sixteen patients (3 with HCM, 1 with DCM, 1 with OMI, 8 with AP, and 3 with other heart diseases) showed type II CD36 deficiency (monocytes expressed CD36 but platelets did not). In all 8 patients with type I CD36 deficiency, there was no BMIPP accumulation in the heart. However, in 13 patients with type II CD36 deficiency, focally reduced BMIPP accumulation was observed, but there were no patients without BMIPP accumulation. CD36 deficiency was observed in a higher proportion (12%) of patients with heart disease in this study than in a reported control study. Type I CD36 deficiency is associated with absence of BMIPP accumulation in the heart, hence it may have an important role in LCFA metabolic disorders and some types of cardiac hypertrophy as well as other heart diseases. |
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| Practice | Clinical medicine |
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| Keywords | 123I-BMIPP, CD36 deficiency, Long-chain fatty acids, Cardiomyopathy, Ischemic heart disease |
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