Japanese
Title99mTc-ECD SPECT を用いたマイクロスフェアモデルに基づく非侵襲的な脳血流測定 - 1点動脈または静脈採血法 -
Subtitle原著
Authors小田野行男*, 大久保真樹**, 高橋誠*, 野口栄吉*, 大滝広雄*, 柴木充朗*, 土橋幸夫*
Authors(kana)
Organization*新潟大学医学部放射線科, **新潟大学医療技術短期大学部診療放射線技術学科
Journal核医学
Volume34
Number12
Page1111-1117
Year/Month1997/12
Article原著
Publisher日本核医学会
Abstract「要旨」99mTc-ECDの静注後, 1点採血した動脈血または静脈血を持続動脈採血の代用とする侵襲性の少ない簡便な定量的脳血流測定法を開発した. microsphere model に基づく持続動脈採血を用いた脳血流測定法では入力関数の積分値が必要である. 本法ではこの値を回帰直線を用いて1点採血した動脈血または静脈血データから算出する. 脳梗塞など9例を対象に回帰直線の設定と1点採血時刻の最適化を図った. 99mTc-ECD静注直後から30分までの頻回動脈採血により得られた入力関数の積分値と, 種々の時刻tで1点採血して得られる4種の血液データ(動脈血の放射能濃度; A(t), それにN値を乗じた値; AN(t), 静脈血の放射能濃度; V(t), それにN値を乗じた値; VN(t))との相関を検討し, 回帰直線を求めた. これらの回帰直線を利用して1点採血データから積分値を算出した場合, 誤差はA(t)は3分, AN(t)は6分, V(t)は20分, およびVN(t)は6分でそれぞれ最小となった. 痴呆など新たな6例を対象に6分の値VN(t=6 min)を用いて脳血流測定を行い, 133Xe吸入法SPECTと比較したところ, 良好な相関(r=0.851)が得られた. 本法は, 1回のSPECT撮像と1回の採血データから脳血流を簡便に精度よく定量できる.
Practice臨床医学：一般
Keywords99mTc-ECD, SPECT, rCBF measurement, Microsphere model, One-point sampling
English
TitleQuantification of Cerebral Blood Flow with 99mTc-ECD SPECT by a Single Arterial or Venous Blood Sample
SubtitleOriginal Articles
AuthorsIkuo ODANO*, Masaki OHKUBO**, Makoto TAKAHASHI*, Eikichi NOGUCHI*, Hiro OHTAKI*, Mitsurou SHIBAKI*, Sachio DOBASHI*
Authors(kana)
Organization*Department of Radiology, Niigata University School of Medicine, **Department of Radiological Technology, College of Biomedical Technology, Niigata University
JournalThe Japanese Journal of nuclear medicine
Volume34
Number12
Page1111-1117
Year/Month1997/12
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractThe purpose of the study is to develop a simple and less invasive method for quantifying regional cerebral blood flow (rCBF) using 99mTc-ECD and SPECT. By employing a microsphere model, a new method to measure rCBF was developed, which required a single arterial or venous sample instead of continuous withdrawal of arterial blood. Using a regression line, the integral of input function of arterial blood from 0 to 30 min was inferred by activity of arterial blood sampled at time t; A(t), by activity multiplied by its octanol extraction rate; AN(t), by activity of venous blood at time t; V(t), and by activity multiplied by its octanol extraction rate; VN(t). The optimum sampling time of arterial or venous blood was examined when mean % error for inference became minimum. Consequently, minimum error of AN(6 min) was 5.5%, A(3 min) was 8.9%, VN(6 min) was 5.9%, and V(20 min) was 10.0%. Quantitative measurement of rCBF using the value of VN(6 min) was performed on other 6 subjects with dementia etc. To validate the method, 133Xe inhalation SPECT studies were also performed on the same subjects. We found a good agreement between them (r = 0.851). The presented one-point sampling methods were simple and less invasive for quantifying rCBF.
PracticeClinical medicine
Keywords99mTc-ECD, SPECT, rCBF measurement, Microsphere model, One-point sampling

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