Japanese
Title99mTc - ECD脳血流SPECTを用いたAcetazolamide負荷前後の定量的評価法 - 測定精度の基礎的検討, 123I - IMP ARG法との比較 -
Subtitle技術報告
Authors伊藤茂樹*, 岩田明子*, 渡邊義雄*, 北野悟*, 吉矢和彦*, 今井秀**
Authors(kana)
Organization*総合大雄会病院放射線科, **脳神経外科
Journal核医学
Volume34
Number11
Page1047-1053
Year/Month1997/11
Article報告
Publisher日本核医学会
Abstract「要旨」連続した99mTc-ECD SPECTによって非侵襲的にacetazolamide負荷前後の局所脳血流量が測定できる松田・竹内らの方法を追試し, その測定精度ならびに123I-IMP ARG法との相関性を検討した. 生理食塩水を負荷するPlacebo Studyでは, 5例80領域における負荷前後の測定値変化率は散乱線を補正しない場合で0.5±8.4%, 散乱線を補正した場合で-0.2±12.6%であり, 散乱線補正の有無に関わらず良好なPlacebo負荷前後の一致性を認めた. 日を変えて検査を繰り返した日差再現性の検討では, 4例64領域における両日の測定値変化率は安静時で-1.1±9.0%, 負荷時で-4.0±11.7%であり, 安静時と負荷時で共に良好な再現性を認めた. 同一例に対して本法と123I-IMP ARG法を施行する相関性の検討では, 5例80領域における両法の測定値相関は安静時でy=.99x+1.47, 相関係数r=0.80, 負荷時でy=0.86x+7.76, r=0.76と得られ, 安静時と負荷時で共に良好な相関性を認めた.
Practice臨床医学：一般
Keywords99mTc-ECD, 123I-IMP, SPECT, rCBF, Diamox, Cerebral perfusion reserve.
English
TitleQuantitative Measurements of Regional Cerebral Blood Flow Using Technetium - 99m - L, L - ECD SPECT Activated with Acetazolamide : Fundamental Study of Measurement's Accuracy, Comparison with 123I - IMP ARG Method
SubtitleTechnical Reports
AuthorsShigeki ITOH*, Akiko IWATA*, Yoshio WATANABE*, Satoru KITANO*, Shu IMAI**, Kazuhiko YOSHIYA*
Authors(kana)
Organization*Division of Radiology, Daiyukai General Hospital, **Department of Neurosurgery, Daiyukai General Hospital
JournalThe Japanese Journal of nuclear medicine
Volume34
Number11
Page1047-1053
Year/Month1997/11
ArticleReport
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]We measured regional cerebral blood How before and after acetazolamide administration using a serial noninvasive method with 99mTc-ECD developed by Matsuda and Takeuchi et al. , and compared the accuracy of measured values with those obtained by the conventional 123I-IMP ARG method. When the regional cerebral blood flow was measured for 80 brain regions in 5 subjects without scatter correction, a differential of 0.5+-8.4% was obtained between values measured before and after physiological saline administration as a placebo. A differential of -0.2+-12.6% was obtained when the same regions were measured with scatter correction. These findings indicated that placebo administration did not affect measured values, regardless of whether scatter correction was performed. When 64 regions in 4 subjects at rest were measured on two successive days, a differential of -1.1+-9.0% was obtained between the values measured on the two days. A differential of -4.0+-11.7% was obtained for the same regions following acetazolamide administration. These findings showed that measurements were reproducible both when subjects were at rest and when they were administered acetazolamide. The above two methods were used for measurement of 80 brain regions in the same 5 subjects for comparison. Measurements of subjects at rest and with acetazolamide administration were performed on separate days. The regression line y=0.99x+1.47, r=0.80, was obtained for the subjects at rest, and y=0.86x+7.76, with r=0.76, for the subjects following acetazolamide administration. These findings demonstrated a good correlation between the values obtained using the two methods. The values obtained using the method of Matsuda and Takeuchi et al. , before and after acetazolamide administration were thus consistent with those reported previously using the conventional method, and the former method proved to be both simple and reliable.
PracticeClinical medicine
Keywords99mTc-ECD, 123I-IMP, SPECT, rCBF, Diamox, Cerebral perfusion reserve.

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