| Japanese |
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| Title | アミロイドーシス4例における123I - MIBG, 201Tl, 99mTc - PYPによる心筋シンチグラフイの検討 |
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| Subtitle | 短報 |
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| Authors | 藤井忠重*, 田中正雄**, 矢崎善一**, 北林浩**, 小泉知展**, 本郷実**, 関口守衛**, 五味勉***, 矢野今朝人***, 伊藤敦子**** |
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| Authors(kana) | |
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| Organization | *信州大学医療技術短期大学部, **信州大学医学部第一内科, ***附属病院中央放射線部, ****放射線科 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 11 |
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| Page | 1033-1039 |
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| Year/Month | 1997/11 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」4例の心アミロイドーシスにおいて, 集積機序, 臨床的意義の異なる123I-MIBG(MIBG), 201Tl(T1), 99mTc-ピロリン酸(PYP)による3種の心筋シンチグラフィを実施し, 心筋集積を検討した. MIBGは原発性の2例で正常, 家族性アミロイドポリニューロパチー(FAP)の2例で欠損ないし減少, Tlは原発性の1例で集積が増加し3例で正常像を示した. PYPはFAP2例で軽度, 原発性2例で中等度の集積を認めた. PYP, MIBG, Tlによる心筋シンチグラフィの組み合わせは, 心アミロイドーシスの存在診断, 交感神経障害の検出, 病態の評価において補助診断法として役立つと考えられる. 「I. はじめに」123I-metaiodobenzylguanidine(MIBG)による心筋シンチグラムは心筋の交感神経分布やカテコラミンの貯蔵状態を描画し, 虚血性心疾患や拡張型心筋症などの補助診断法として利用され, 特に家族性アミロイドポリニューロパチー(FAP)など, 心臓の自律神経障害を直接的に描画, 診断する方法として注目されている. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-metaiodobenzylguanidine, 99mTc-pyrophosphate, 201Tl, Myocardial scintigraphy, Cardiac amyloidosis. |
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| English |
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| Title | Myocardial Scintigraphic Studies with 123I - MIBG, 201Tl and 99mTc - PYP in Patients with Cardiac Amyloidosis |
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| Subtitle | Short Communications |
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| Authors | Tadashige FUJII*, Masao TANAKA**, Yosikazu YAZAKI**, Hiroshi KITABAYASHI**, Tomonori KOIZUMI**, Minoru HONGO**, Morie SEKIGUCHI**, Atsuko ITOH***, Tsutomu GOMI****, Kesato YANO**** |
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| Authors(kana) | |
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| Organization | *School of Allied Medical Sciences, **Department of Internal Medicine, ***Department of Radiology, ****Division of Radiology, Shinshu University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 11 |
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| Page | 1033-1039 |
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| Year/Month | 1997/11 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Myocardial scintigraphic studies, using 123I-metaiodobenzylguanidine(MIBG), 99mTc-pyrophosphate(PYP)and 201Tl were performed in 4 patients with cardiac amyloidosis. In MIBG myocardial images, 2 patients with familial amyloid polyneuropathy(FAP)showed complete or partial defect and the other 2 with primary amyloidosis had normal myocardial uptake of MIBG. In PYP myocardial images, diffuse myocardial uptake of PYP was mild in 2 patients with FAP and moderate in the other 2. 201Tl myocardial images revealed normal myocardial uptake of 201Tl in 2 patients with FAP and 1 with primary amyloidosis, and intense myocardial uptake in the other one with primary amyloidosis. These results suggest that myocadial scintigraphies with PYP and 201Tl may be useful for the detection of cardiac amyloidosis and estimation of its pathophysiology. And MIBG myocardial scintigraphy may provide useful information about sympathetic nerve abnormalities which vary with type of the fibril protein, clinical syndromes and disease process of cardiac amyloidosis. |
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| Practice | Clinical medicine |
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| Keywords | 123I-metaiodobenzylguanidine, 99mTc-pyrophosphate, 201Tl, Myocardial scintigraphy, Cardiac amyloidosis. |
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