Japanese
Title超早期SPECT像とマイクロスフェア法を用いた123I - IMPによる定量的脳血流測定
Subtitle短報
Authors難波宏樹*, 柳沢正道**, 戸川貴史**, 木下富士美**, 末吉貫爾*, 油井信春**
Authors(kana)
Organization*千葉県がんセンター脳神経外科, **核医学診療部
Journal核医学
Volume34
Number11
Page1027-1031
Year/Month1997/11
Article報告
Publisher日本核医学会
Abstract「要旨」3検出器回転型SPECT装置にてIMP投与後超早期SPECT像(4-6分)を撮像し, この像を用いたmicrosphere(MS)法により, 若年健常者における局所脳血流(CBF)を定量的に測定した. 一般に早期像とされているIMP投与40分後の像の放射能と超早期像の放射能の各脳部位における比は脳血流値と負の関係を示した. このことは一般のMS法では血流値の高い部位では血流値が過小評価され, 血流値の低い部位では過大評価される可能性を示唆している. 超早期像を用いたMS法による大脳皮質の平均血流量はオクタノール抽出率を0.75とした時52.5±7.0(ml/100g/min. mean±SD)となり, 過去に報告されたPETによる値とほぼ一致した. MS法は理論的に単純なモデルであり, 洗い出し以外の補正を必要としないので疾患脳においても広く適用可能と考えられる. 今後高性能SPECT装置の普及に伴いMS法を利用した各種脳疾患の血流測定が行われるものと思われる.
Practice臨床医学：一般
Keywords123I-IMP, CBF, Microsphere model, Super-early SPECT image, Normal value.
English
TitleQuantitative Measurement of Cerebral Blood Flow by the Microsphere Model with Super - Early 123I - IMP Brain SPECT
SubtitleShort Communications
AuthorsHiroki NAMBA*, Masamichi YANAGISAWA**, Takashi TOGAWA**, Fujimi KINOSHITA**, Kanji SUEYOSHI*, Nobuharu YUI**
Authors(kana)
Organization*Division of Neurological Surgery, **Division of Nuclear Medicine, Chiba Cancer Center Hospital
JournalThe Japanese Journal of nuclear medicine
Volume34
Number11
Page1027-1031
Year/Month1997/11
ArticleReport
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]Cerebral blood flow(CBF)was quantitatively measured in 6 healthy young volunteers based on "super-early" acquisition of N-isopropyl-p-[123I]iodoamphetamine(IMP)brain SPECT obtained 4-6 min after IMP injection with a three-head rotating gamma camera and the microsphere(MS)model. The ratio of radioactivity(count/pixel/min)in the conventional early SPECT image(taken 25-55 min after IMP injection)to that in the super-early image for each brain region negatively correlated with regional CBF value obtained with the "super-early" MS method. This indicates that wash-out of IMP from the regions with higher CBF is faster than that from the regions with lower CBF and that CBF values are underestimated with the conventional MS method in regions with higher CBF. Regional CBF was quantitatively measured with the "super-early" MS method and the ARG method, a recently developed method based on two compartment model. The mean cortical CBF was 52.5+-7.0(ml/100g/min, mean+-SD)with the"super-early" MS method and 47.5+-3.3 with the ARG method. The CBF values obtained with the "super-early" MS method agreed with those previously reported with positron emission tomography. Since the MS method is theoretically the simplest model, the "super-early" MS method can be applied various disorders of the central nervous system where the behavior of IMP is not fully understood.
PracticeClinical medicine
Keywords123I-IMP, CBF, Microsphere model, Super-early SPECT image, Normal value.

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