| Japanese |
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| Title | 心肺疾患における123I - MIBG肺集積の検討 - 肺集積度と肺集積減弱例の検討 - |
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| Subtitle | 原著 |
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| Authors | 藤井忠重*, 田中正雄**, 矢崎善一**, 北林浩**, 小泉知展**, 関口守衛**, 五味勉***, 矢野今朝人***, 伊藤敦子**** |
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| Authors(kana) | |
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| Organization | *信州大学医療技術短期大学部, **信州大学医学部第一内科, ***附属病院中央放射線部, ****放射線科 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 11 |
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| Page | 1005-1011 |
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| Year/Month | 1997/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」心肺疾患64例において, 123I-MIBG(MIBG)の肺集積を視覚的および定量的(上縦隔に対する一側肺の1画素当たりの平均カウント比, Lu/M)に検討した. Lu/Mの右肺, 左肺の値は心不全(-)群で1.56±0.16, 1.28±0.16, 心不全(+)群で1.45±0.16, 1.19±0.15であり, 視覚的にも大多数例が(++)以上の明瞭な肺集積を示した. 一方, 心疾患に慢性肺気腫を合併した3例および皮膚筋炎に伴う間質性肺炎を合併した1例では, 肺集積は著明に減弱し, 右肺, 左肺のLu/Mも各々1.20, 1.17;1.17, 1.13;1.01, 0.97;1.27, 0.94と低値を示した. 以上の結果と, MIBGが肺血管内皮に能動的に摂取されるとの報告を考慮すると, MIBG肺集積は肺血管内皮の状態を反映する指標として利用しうる可能性が示唆され, さらに症例の蓄積が望まれる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-metaiodobenzylguanidine, Lung uptake, Heart diseases, Chronic pulmonary emphysema, Dermatomyositis. |
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| English |
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| Title | Estimation of 123I - Metaiodobenzylguanidine Lung Uptake in Heart and Lung Diseases - With Reference to Lung Uptake Ratio and Decrease of Lung Uptake - |
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| Subtitle | Original Articles |
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| Authors | Tadashige FUJII*, Masao TANAKA**, Yoshikazu YAZAK**, Hiroshi KITABAYASHI**, Tomonori KOIZUMI**, Morie SEKIGUCHI**, Tsutomu GOMI***, Kesato YANO***, Atsuko ITOH**** |
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| Authors(kana) | |
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| Organization | *School of Allied Medical Sciences, **Department of Internal Medicine, ***Division of Radiology, ****Department of Radiology, Shinshu University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 11 |
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| Page | 1005-1011 |
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| Year/Month | 1997/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]123I-metaiodobenzylguanidine(MIBG)myocardial scintigraphy was performed in 64 patients with heart and lung diseases. Distribution of MIBG in the chest was evaluated by planar images, using counts ratios of the heart to the mediastinum(H/M)and the unilateral lung to the mediastinum(Lu/M). Most of patients with heart diseases showed obvious lung uptake of MIBG. The ratios of H/M were 1.75+-0.20 in the group without heart failure and 1.55+-0.19 in the group with heart failure. The ratios of Lu/M in the right and left lung were 1.56+-0.16 and 1.28+-0.16 in the group without heart failure. And those were 1.45+-0.16 and 1.19+-0.15 in the group with heart failure. But 3 patients complicated with chronic pulmonary emphysema and one patient with interstitial pneumonia due to dermatomyositis showed markedly decreased lung uptake. The ratios of Lu/M in the right and left lung of these patients were 1.20, 1.17; 1.17, 1.13; 1.01, 0.97 and 1.27, 0.94, respectively. These results suggest that the lung uptake of MIBG may reflect the state of pulmonary endothelial cell function in clinical situations, considering that it has been demonstrated that MIBG may be useful as a marker of pulmonary endothelial cell function in the isolated rat lung. |
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| Practice | Clinical medicine |
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| Keywords | 123I-metaiodobenzylguanidine, Lung uptake, Heart diseases, Chronic pulmonary emphysema, Dermatomyositis. |
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