| Japanese |
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| Title | 慢性右室負荷疾患における123I-BMIPP心筋シンチグラフィの臨床的意義 - 右室負荷心筋における脂肪酸代謝の検討 - |
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| Subtitle | 原著 |
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| Authors | 武藤浩* |
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| Organization | *東邦大学医学部第一内科 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 10 |
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| Page | 917-924 |
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| Year/Month | 1997/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 要旨 123I-BMIPP (BMIPP) を用いて慢性右室負荷疾患の右室圧の推定ならびに右室負荷心筋における脂肪酸代謝異常の有無について201TlCl (Tl) と比較検討した. 対象は右室収縮期圧 (RVSP) 35mmHg以上を呈した慢性右室負荷症例20例. Tl, BMIPPのdual心筋SPECTを行い, 両心室自由壁のカウント比 (RVc / LVc) を求め, RVSP, 両心室収縮期圧比 (RVSP / LVSP) と比較した. さらにRVSPの重症度から3群に分類し, BMIPPとTlの取り込み比 (BMJPP / Tl) を各群で比較した. TlではRVc / LVcとRVSPとの間にr=0.51 (p<0.05), RVSP / LVSPとの間にr=0.59 (p<0.01) と有意な正の相関が示されたが, BMIPPでは相関は認められなかった. BMIPP / TlはRVSPが80mmHg以上の群 (0.82±0.06) では80mmHg未満の群 (35〜49mmHg : 0.91±0.07, 50〜79mmHg : 0.98±0.04) に比し有意な低下が示された. 以上より右室圧の推定にはBMIPPよりTlが優れていた. 右室負荷疾患ではRVSPが80mmHg以上を呈した場合, 右室心筋の脂肪酸代謝異常が出現することが示された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-BMIPP myocardial SPECT, Chronic right ventricular overload, Fatty acid metabolism. |
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| English |
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| Title | Assessment of 123I-β-Methyl Iodophenyl Pentadecanoic Acid (BMIPP) Myocardial Scintigraphy in Patients of Chronic Right Ventricular Overload - Fatty Acid Metabolism in Right Ventricular Myocardium - |
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| Subtitle | Original Articles |
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| Authors | Hiroshi MUTOH |
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| Authors(kana) | |
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| Organization | First Department of Internal Medicine, Toho University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 10 |
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| Page | 917-924 |
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| Year/Month | 1997/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | An investigation on the right ventricular pressure level and the abnormalities in the fatty acid metabolism of myocardium was made using 123I-β-methyl-iodophenyl pentadecanoic acid (BMIPP) myocardial SPECT in patients with chronic right ventricular overloading. Twenty patients who presented with right ventricular systolic pressure (RVSP) of 35 mmHg or more were used as the subjects. Dual myocardial SPECT with 201TlCl (Tl) and BMIPP was carried out for the subjects and RVc / LVc, a ratio of radioactivity count incorporated in the right ventricular free wall to the left one was determined for Tl and BMIPP. And the correlations between RVc / LVc and RVSP, and RVc / LVc and RVSP / LVSP were examined. The subjects were classified into 3 group based on the RVSP levels and the count ratio, BMIPP / Tl was compared among the three groups. With respect of Tl uptake, there were significant, positive correlations between RVc / LVc and RVSP (correlation coefficient r=051, p<0.05) and between RVc / LVc and RVSP / LVSP (correlation coefficient r=0.59, p<0.01). On the other hand, no significant correlation was found between them with respect of the uptake of BMIPP. The BMIPP / Tl ratio in the group with higher than 80 mmHg of RVSP was 0.82+-0.06, which was significantly lower than the ratio's for two groups of less than 80 mmHg ; 0.91+-0.07 and 0.98+-0.04 in the group with 35-49 and 50-79 mmHg of RVSP, respectively. These results show that when compared with BMIPP, Tl is superior for the estimation of right ventricular pressure. For the patients with right ventricular overloading, it was suggested that when RVSP reaches 80 mmHg or more, there appear some disorders in the fatty acid metabolism in the right ventricular myocardium. |
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| Practice | Clinical medicine |
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| Keywords | 123I-BMIPP myocardial SPECT, Chronic right ventricular overload, Fatty acid metabolism. |
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