| Japanese |
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| Title | 加齢に伴う健常者脳血流量の変化 - 99mTc-ECD Patlak-Plot法による平均脳血流量mCBFの検討 - |
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| Subtitle | 原著 |
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| Authors | 川畑信也*, 大東信幸**, 白井史恵**, 原滋** |
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| Authors(kana) | |
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| Organization | *成田記念病院神経内科, **成田記念病院放射線科 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 10 |
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| Page | 909-916 |
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| Year/Month | 1997/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 要旨 健常者61名を対象に99mTc-ECD Patlak-Plot法により算出された平均脳血流量mCBFについて加齢に伴う変化を検討した. 加齢に従ってmCBFは緩やかな減少を示していた (Y=-0.27X+65.07, R=-0.41, p=0.001). mCBFは, 50歳代48.4±4.7ml/100g/min, 60歳代49.9±5.9ml/100g/min, 70歳代46.4±6.5ml/100g/min, 80歳代38.0±3.7ml/100g/min, 90歳代38.9ml/100g/minを示し, 70歳代から緩徐な減少がみられた. 女性の各年齢層におけるmCBFは男性のそれらに比べて有意に高値を示していた. 加齢に伴うBPIの変化は, mCBFとほぼ同様の減少を示していた. 対象を高血圧歴や喫煙, 飲酒の有無から分類した結果では, 各年齢層におけるmCBFに明らかな差異は認められなかった. 健常者と老年期痴呆のmCBFを比較すると, 60歳代, 70歳代の健常者mCBFは老年期痴呆と比べて有意に高値を示していたが, 80歳代, 90歳代では, 両者の間で有意な差異を認めなかった. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-ECD, Aging, Mean cerebral blood flow, SPECT. |
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| English |
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| Title | Reduction in Mean Cerebral Blood Flow Measurements Using 99mTc-ECD-SPECT during Normal Aging |
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| Subtitle | Original Articles |
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| Authors | Nobuya KAWAHATA*, Nobuyuki DAITOH**, Fumie SHIRAI**, Shigeru HARA** |
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| Authors(kana) | |
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| Organization | *Department of Neurology, **Department of Radiology, Narita Memorial Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 10 |
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| Page | 909-916 |
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| Year/Month | 1997/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Mean cerebral blood flow (mCBF) was measured by SPECT using the 99mTc-ECD-Patlak-Plot method in a selected group of 61 normal non-hospitalized subjects aged 51 to 91 years. The mCBF values showed 48.4+-4.7ml/100g/min in aged 50-59 years group, 49.9+-5.9ml/100g/min in aged 60-69 years group, 46.4+-6.5ml/100g/min in aged 70-79 group, 38.0+-3.7ml/100g/min in aged 80-89 years group, 38.9ml/100g/min in aged 90-99 years group. There was a statistically significant reduction of mCBF with advancing age (R=-0.41 ; p=0.001). Women have significantly higher mCBF values than men up to aged 70 years group. In this study, there was no significant laterality in the mCBF between right and left hemispheres in all decade groups. The history of hypertension, alcohol consumption, and cigarette smoking failed to show significant difference in the mCBF values. The present study shows that normal aging is associated with mCBF reduction. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-ECD, Aging, Mean cerebral blood flow, SPECT. |
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