| Japanese |
|---|
| Title | 非侵襲的マイクロスフェア法によるIMP脳血流SPECTの定量化 - 動態イメージングによる入力関数積分値の推定 - |
|---|
| Subtitle | 原著 |
|---|
| Authors | 米倉義晴*, 杉原秀樹**, 谷口義光**, 青木悦雄**, 古市健治**, 宮崎吉春*** |
|---|
| Authors(kana) | |
|---|
| Organization | *福井医科大学高エネルギー医学研究センター, **公立高島総合病院, ***公立能登総合病院 |
|---|
| Journal | 核医学 |
|---|
| Volume | 34 |
|---|
| Number | 10 |
|---|
| Page | 901-908 |
|---|
| Year/Month | 1997/10 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 要旨 123I-IMPの初期循環動態とSPECT画像から脳血流量の定量的測定を行う方法を開発した. 本法は, IMPの持続動脈採血法 (マイクロスフェア法) を基本として, その動脈採血カウントを非侵襲的に推定する方法である. 投与量 (Q) を中心循環系からの5分間の送り出し率で補正して全身に送られたIMP量とし, これを心拍出量 (CO) で除することによって投与後5分までの入力関数の積分値を推定し, マイクロスフェア法に基づいて脳血流量の定量値を求めた. 23例において, IMPの右心通過時のカウントから心拍出量の指標を算出する方法を適用し, 同時に測定した超音波ドップラー法により測定した心拍出量との比較により両者の回帰式を求め, これに基づいて心拍出量を推定した. 本法を用いて健常男性ボランティア6名で得られた脳血流量の定量値は安定した値を示し, 臨床的に利用できる可能性が示された. 本法の臨床応用に際しては, 投与の方法についての検討が必要である. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | SPECT, Regional cerebral blood flow, Quantification, Microsphere model, Input function. |
|---|
| English |
|---|
| Title | Quantification of Brain Perfusion SPECT with N-Isopropyl-p-Iodoamphetamine Using Noninvasive Microsphere Method : Estimation of Arterial Input by Dynamic Imaging |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Yoshiharu YONEKURA*, Hideki SUGIHARA**, Yoshimitsu TANIGUCHI**, Etsuo AOKI**, Kenji FURUICHI**, Yoshiharu MIYAZAKI*** |
|---|
| Authors(kana) | |
|---|
| Organization | *Biomedical Imaging Research Center, Fukui Medical University, **Takashima General Hospital, ***Noto General Hospital |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 34 |
|---|
| Number | 10 |
|---|
| Page | 901-908 |
|---|
| Year/Month | 1997/10 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | We have developed a noninvasive method to quantify brain perfusion SPECT with 123I-N-isopropyl-p-iodoamphetamine (IMP) using serial dynamic planar imaging of the initial transit phase. The method is based on the microsphere model, but does not require arterial sampling. Serial dynamic planar imaging was performed for 6 min after the bolus injection of IMP (167MBq in 1.5 ml), followed by additional planar imaging at 20 min and SPECT scan thereafter. The total arterial input to the brain during the initial 5 min after injection was estimated by the injected dose, with the correction of the lung retention, divided by cardiac output (CO). CO was estimated from the initial transit of IMP in the right heart. Cardiac output index (COI), obtained from the integral of the first transit of IMP in the right heart divided by the injected dose, was calibrated by CO measured by Doppler ultrasonography. Regional cerebral blood flow (rCBF) obtained by this method in normal subjects was acceptable. However, the results may be influenced by the injection technique, and careful attention should be considered for clinical application of this method. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | SPECT, Regional cerebral blood flow, Quantification, Microsphere model, Input function. |
|---|