| Japanese |
|---|
| Title | 99mTc-GSA dynamic SPECTによる全肝および局所肝機能の評価 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 藤澤英文*, 篠塚明*, 武中泰樹* |
|---|
| Authors(kana) | |
|---|
| Organization | *昭和大学医学部放射線科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 34 |
|---|
| Number | 10 |
|---|
| Page | 885-899 |
|---|
| Year/Month | 1997/10 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 要旨 局所および全肝機能評価のために99mTc-GSAによるdynamic SPECTを各種肝疾患患者58例, 健常志願者5例に施行し, その有用性を検討した. 解析はSPECT画像の各マトリックスの時間放射能曲線を最小二乗法近似して肝摂取率 (K値) を算出し, K値と各ボクセルの機能的容積との積を肝機能指数とし, 肝全体での総和を全肝機能指数とした. 全肝機能指数は各種肝機能検査やHH15, LHL15などと良好な相関を示し, Child-Pugh肝障害重症度分類の各stage間に有意差が得られた. この方法はROIの設定が不要でほとんど自動的に処理できるので, 操作者間でのデータのバラツキがなく客観性に優れている. また, 肝機能指数のmapを作成することで肝局所機能を三次元的に評価でき, 肝切除後の残存肝機能の推定も可能であり, 臨床的に有用な方法である. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | 99mTc-GSA, Dynamic SPECT, Total liver function, Regional liver function, Functional map. |
|---|
| English |
|---|
| Title | Study on the Evaluation of Total and Regional Liver Function Using 99Tc-GSA Dynamic SPECT |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Hidefumi FUJISAWA, Akira SHINOZUKA, Hiroki TAKENAKA |
|---|
| Authors(kana) | |
|---|
| Organization | Department of Radiology, Showa University School of Medicine |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 34 |
|---|
| Number | 10 |
|---|
| Page | 885-899 |
|---|
| Year/Month | 1997/10 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | To evaluate regional and total liver function, 99mTc-GSA dynamic SPECT was studied in 58 patients with various liver disease and 5 normal volunteers. Using dual-head gamma camera, 60 projection data (90 seconds / rotation) were acquired to obtain SPECT imaging. Forty continuous SPECT were obtained for 60 minutes. Time activity curve (TAC) of each voxel was created. The TAC was assumed to be equally the function of C(t)=Cmax(l-e-kt). The liver uptake rate (K value) was calculated using the least squares method. The product of K value and functional volume of each voxel was defined as liver functional index and the sum of the indices was defined as total liver functional index. The total liver functional index had good correlation with various liver function test, HH15, LHL15, and the index showed significant difference between each group of Child-Pugh's liver dysfunction stage. Because of unnecessariness of setting up the ROI, this method is simple and the result is no difference among operaters. Three-dimensional liver functional index map exactly shows regional liver function. So that, this method seems to be useful for predicting the residual liver function after hepatectomy. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | 99mTc-GSA, Dynamic SPECT, Total liver function, Regional liver function, Functional map. |
|---|