| Japanese |
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| Title | MRIと比較し131I-MIBGシンチグラフィが経過観察に有用であった成人の神経芽細胞腫骨髄転移の1例 |
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| Subtitle | 症例報告 |
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| Authors | 甲田真由子*, 岡村光英*, 小橋肇子*, 河邉讓治**, 越智宏暢**, 山田龍作*, 日野雅之*** |
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| Authors(kana) | |
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| Organization | *大阪市立大学医学部放射線科, **核医学研究室, ***血液内科 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 9 |
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| Page | 821-826 |
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| Year/Month | 1997/9 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」26歳女性の後腹膜原発神経芽細胞腫骨髄転移症例における治療前後の骨髄病変の評価に131I-MIBGシンチグラフィが有用であったのでMRIと対比し報告する. 成人発症の神経芽細胞腫はまれとされている. 治療前の131I-MIBGシンチグラムでは, 左上腹部, 骨盤骨, 脊椎に異常集積を認め, 腸骨生検で神経芽細胞腫の骨髄転移が判明した. 4回の化学療法に伴い異常集積は減少したが, 4回目の治療後のMIBGシンチグラムでわずかに右仙腸関節部に異常集積を認め, 組織学的にも腫瘍の残存を確認した. MRIでは治療前, 腸骨はT1強調像で低信号, T2強調像で高信号を示し, 転移を捉え得た. しかし, 治療後, 改善か否かの評価は困難であった. MIBGシンチグラフィはMRIに比べ, 神経芽細胞腫骨髄転移の全身の病巣の拡がりの把握, 治療による改善の評価に有用であった. 「I. はじめに」神経芽細胞腫の成人発症はきわめてまれとされている. |
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| Practice | 臨床医学：一般 |
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| Keywords | Adult neuroblastoma, Bone metastases, 131I-MIBG scintigraphy, MRI. |
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| English |
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| Title | A Case of an Adult Neuroblastoma with Bone - Marrow Metastases : 131I-MIBG Scintigraphy in Comparison with MRI |
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| Subtitle | Case Reports |
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| Authors | Mayuko KODA*, Terue OKAMURA*, Toshiko KOBASHI*, Joji KAWABE**, Hironobu OCHI**, Ryusaku YAMADA*, Masayuki HINO*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Osaka City University Medical School, **Division of Nuclear Medicine, Osaka City University Medical School, ***Department of Hematopathology, Osaka City University Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 9 |
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| Page | 821-826 |
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| Year/Month | 1997/9 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]To detect a primary neuroblastoma lesion and its metastases, 131I-MIBG scintigraphy was performed for a 24-year-old woman who had a high level of serum catecholamine. 131I-MIBG scintigrams showed high radioactivity in the left upper quadrant, pelvic bone, and vertebral bodies. A biopsy of the pelvic bone revealed metastasis from the neuroblastoma. After four chemotherapy courses, the accumulation of 131I-MIBG decreased after each course;however, scintigraphy performed after the last chemotherapy course showed focal mild uptake in the right sacroiliac. The presence of residual tumor in the sacroiliac was confirmed histologically. On the other hand, T1-weighted and T2-weighted MR images performed before the treatment showed low signal intensity and high signal intensity in the pelvic bone, respectively. After the fourth chemotherapy course, T2-weighted MR images showed low signal intensity in the pelvic bone;however, it was difficult to determinate whether it should improve. To assess the effect of treatment of neuroblastoma, 131I-MIBG scintigraphy was considered more useful than MRI. |
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| Practice | Clinical medicine |
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| Keywords | Adult neuroblastoma, Bone metastases, 131I-MIBG scintigraphy, MRI. |
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